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Last Updated: October 4, 2024

CLINICAL TRIALS PROFILE FOR NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE


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All Clinical Trials for Nicardipine Hydrochloride In 0.9% Sodium Chloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00007592 ↗ Hypertension Screening and Treatment Program Completed US Department of Veterans Affairs 1989-06-01 Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
NCT00007592 ↗ Hypertension Screening and Treatment Program Completed VA Office of Research and Development 1989-06-01 Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
NCT00093925 ↗ Clevidipine in the Postoperative Treatment of Hypertension (ECLIPSE-NIC) Completed The Medicines Company Phase 3 2004-05-01 The purpose of this study is to establish the safety of clevidipine in the treatment of postoperative hypertension. Approximately 250-500 patients with postoperative hypertension after undergoing coronary artery bypass grafting (CABG), off-pump coronary artery bypass (OPCAB) or minimally invasive direct coronary artery bypass (MIDCAB) surgery and/or valve replacement/repair procedures were anticipated to be randomly assigned to one of two treatment groups: clevidipine or nicardipine.
NCT00137501 ↗ Two Dose Regimens of Nifedipine for the Management of Preterm Labor Terminated American University of Beirut Medical Center Phase 3 2003-05-01 Preterm birth is one of the most important causes of perinatal morbidity and mortality worldwide. Prevention and treatment of preterm labor is important, not as an end in itself, but as a means of reducing adverse events for the neonate. A wide range of tocolytics, drugs used to suppress uterine contractions, have been tried. Magnesium sulfate (MgSO4) is the most widely used tocolytic at the American University of Beirut Medical Center despite the fact that an effective tocolytic role of MgSO4 has never been established. Moreover, the currently available data are suggestive of deleterious fetal effects of MgSO4 in the setting of preterm labor to the extent that some authorities are recommending abandoning it for routine use as a tocolytic therapy. Calcium channel blockers have the ability to inhibit contractility in smooth muscle cells. Consequently, nifedipine has emerged as an effective and rather safe alternative tocolytic agent for the management of preterm labor after several studies have shown that the use of nifedipine in comparison with other tocolytics is associated with a more frequent successful prolongation of pregnancy, resulting in significantly fewer admissions of newborns to the neonatal intensive care unit, and is associated with a lower incidence of respiratory distress syndrome. The unequivocal impact of this method of tocolysis on short term postponement of delivery and the opportunity that this provides for affecting in-utero transfer and steroid administration has prompted many investigators to recommend focusing future trials on testing different dose regimens of nifedipine. To the best of the investigators' knowledge, no study comparing two different dose regimens of nifedipine has been previously published in the literature. The objective of their study is to compare the effectiveness of a high versus a low dose regimen in a total of 200 patients admitted with the diagnosis of preterm labor between 24 and 34 weeks of gestation. In addition, the investigators' study will try to assess the safety profile of the 2 dose regimens on the mother and the neonate by assessing a selected number of outcome variables. The data generated will be used to change their protocol for managing patients presenting with threatened preterm delivery and will fill the existing gap regarding the most effective and safest dose regimen of nifedipine in such patients.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Nicardipine Hydrochloride In 0.9% Sodium Chloride

Condition Name

Condition Name for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Intervention Trials
Hypertension 10
Intracerebral Hemorrhage 3
Subarachnoid Hemorrhage 3
Coronary Artery Disease 2
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Condition MeSH

Condition MeSH for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Intervention Trials
Hypertension 13
Hemorrhage 9
Cerebral Hemorrhage 6
Stroke 5
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Clinical Trial Locations for Nicardipine Hydrochloride In 0.9% Sodium Chloride

Trials by Country

Trials by Country for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Location Trials
United States 92
China 14
Japan 5
Australia 5
Korea, Republic of 5
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Trials by US State

Trials by US State for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Location Trials
Ohio 6
Illinois 6
New York 6
Pennsylvania 5
Tennessee 4
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Clinical Trial Progress for Nicardipine Hydrochloride In 0.9% Sodium Chloride

Clinical Trial Phase

Clinical Trial Phase for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Clinical Trial Phase Trials
Phase 4 14
Phase 3 11
Phase 2 7
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Clinical Trial Status

Clinical Trial Status for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Clinical Trial Phase Trials
Completed 22
Not yet recruiting 10
Recruiting 6
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Clinical Trial Sponsors for Nicardipine Hydrochloride In 0.9% Sodium Chloride

Sponsor Name

Sponsor Name for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Sponsor Trials
Yonsei University 4
The Medicines Company 4
National Institute of Neurological Disorders and Stroke (NINDS) 3
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Sponsor Type

Sponsor Type for Nicardipine Hydrochloride In 0.9% Sodium Chloride
Sponsor Trials
Other 148
Industry 12
NIH 3
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