To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic
acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result
in significant reduction in total mortality over a five year period. Secondarily, to
determine whether the degree to which these drugs changed serum lipids was correlated with
any effect on mortality and morbidity rates; to gain further information on the long-term
prognosis of myocardial infarction (by studying the control group as intensively as the
treatment group); to acquire further experience and knowledge concerning the techniques and
methodology of long-term clinical trials; to determine, in a substudy, the effectiveness of
aspirin, a platelet inhibitor, in reducing recurrences of myocardial infarction.
To evaluate, in asymptomatic and symptomatic participants with peripheral arterial disease,
the feasibility of recruitment and adherence, efficacy and safety of HDL-C raising along
with effective control of LDL-C levels, antioxidant therapy, antithrombotic therapy, and
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