To determine by sequential coronary arteriography whether a lipid-lowering diet with and
without lipid-lowering drugs could reverse coronary artery disease in normocholesterolemic
patients. Also, to test whether fish oil supplements could improve human coronary
atherosclerosis. Finally, to determine the effect of combination therapy with lipid-reducing
drugs in patients with coronary heart disease and "normal" cholesterol levels. At least three
clinical trials were conducted.
To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic
acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result
in significant reduction in total mortality over a five year period. Secondarily, to
determine whether the degree to which these drugs changed serum lipids was correlated with
any effect on mortality and morbidity rates; to gain further information on the long-term
prognosis of myocardial infarction (by studying the control group as intensively as the
treatment group); to acquire further experience and knowledge concerning the techniques and
methodology of long-term clinical trials; to determine, in a substudy, the effectiveness of
aspirin, a platelet inhibitor, in reducing recurrences of myocardial infarction.
To determine whether there were any long term sequelae of the drugs used in the Coronary Drug
Project (estrogens, dextrothyroxine, nicotinic acid, clofibrate).
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