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Last Updated: May 26, 2022

CLINICAL TRIALS PROFILE FOR NIACIN


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All Clinical Trials for Niacin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000461 ↗ Harvard Atherosclerosis Reversibility Project (HARP) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 1986-12-01 To determine by sequential coronary arteriography whether a lipid-lowering diet with and without lipid-lowering drugs could reverse coronary artery disease in normocholesterolemic patients. Also, to test whether fish oil supplements could improve human coronary atherosclerosis. Finally, to determine the effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. At least three clinical trials were conducted.
NCT00000482 ↗ Coronary Drug Project Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1965-04-01 To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result in significant reduction in total mortality over a five year period. Secondarily, to determine whether the degree to which these drugs changed serum lipids was correlated with any effect on mortality and morbidity rates; to gain further information on the long-term prognosis of myocardial infarction (by studying the control group as intensively as the treatment group); to acquire further experience and knowledge concerning the techniques and methodology of long-term clinical trials; to determine, in a substudy, the effectiveness of aspirin, a platelet inhibitor, in reducing recurrences of myocardial infarction.
NCT00000483 ↗ Coronary Drug Project Mortality Surveillance Completed National Heart, Lung, and Blood Institute (NHLBI) N/A 1981-06-01 To determine whether there were any long term sequelae of the drugs used in the Coronary Drug Project (estrogens, dextrothyroxine, nicotinic acid, clofibrate).
NCT00000512 ↗ Familial Atherosclerosis Treatment Study Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1984-01-01 To compare the effects of two intensive lipid-lowering regimens with conventional therapy on coronary atherosclerosis as assessed by arteriography.
NCT00000512 ↗ Familial Atherosclerosis Treatment Study Completed University of Washington Phase 3 1984-01-01 To compare the effects of two intensive lipid-lowering regimens with conventional therapy on coronary atherosclerosis as assessed by arteriography.
NCT00000539 ↗ Arterial Disease Multifactorial Intervention Trial (ADMIT) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1992-09-01 To evaluate, in asymptomatic and symptomatic participants with peripheral arterial disease, the feasibility of recruitment and adherence, efficacy and safety of HDL-C raising along with effective control of LDL-C levels, antioxidant therapy, antithrombotic therapy, and their combinations.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Niacin

Condition Name

Condition Name for Niacin
Intervention Trials
Dyslipidemia 21
Hypercholesterolemia 16
Atherosclerosis 12
Cardiovascular Diseases 11
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Condition MeSH

Condition MeSH for Niacin
Intervention Trials
Dyslipidemias 40
Hypercholesterolemia 23
Coronary Artery Disease 22
Coronary Disease 20
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Clinical Trial Locations for Niacin

Trials by Country

Trials by Country for Niacin
Location Trials
United States 226
Canada 30
Switzerland 7
China 5
Germany 5
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Trials by US State

Trials by US State for Niacin
Location Trials
California 21
Pennsylvania 18
Maryland 15
Texas 11
Florida 10
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Clinical Trial Progress for Niacin

Clinical Trial Phase

Clinical Trial Phase for Niacin
Clinical Trial Phase Trials
Phase 4 46
Phase 3 37
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Niacin
Clinical Trial Phase Trials
Completed 117
Terminated 18
Recruiting 14
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Clinical Trial Sponsors for Niacin

Sponsor Name

Sponsor Name for Niacin
Sponsor Trials
Merck Sharp & Dohme Corp. 29
National Heart, Lung, and Blood Institute (NHLBI) 16
Abbott 11
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Sponsor Type

Sponsor Type for Niacin
Sponsor Trials
Other 162
Industry 88
NIH 33
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