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Generated: November 18, 2018

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CLINICAL TRIALS PROFILE FOR NALBUPHINE HYDROCHLORIDE

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Clinical Trials for Nalbuphine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00155233 Interaction Between Nalbuphine and Morphine in PCA Unknown status National Taiwan University Hospital Phase 4 1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. This study was designed to investigate the interaction between nalbuphine and morphine
NCT00200564 Ketamine and Postoperative Analgesia in Children Unknown status Nantes University Hospital Phase 4 The benefit of small doses of ketamine has been demonstrated for postoperative analgesia in adults but remains unproved in children. The investigators' purpose is to evaluate the effects of continuous intravenous small doses of ketamine versus placebo to improve the quality of postoperative analgesia in children (6 months to 6 years of age). Caudal anesthesia is performed for intraoperative analgesia and all children receive paracetamol, a non-steroidal anti-inflammatory and continuous intravenous nalbuphine.
NCT00323154 Nalbuphine for the Treatment of Opioid Induced Pruritus in Children Completed University of British Columbia Phase 3 Itching is a frequent and disturbing side effect of the use of pain medication such as morphine. In the post-operative period, it can be more distressing to pediatric patients than their pain. The current first line treatment, an antihistamine (Benadryl), has a low efficacy. This treatment causes sleepiness and may be dangerous when used in combination with other drugs. Nalbuphine has analgesic properties similar to morphine as well as the ability to reverse some morphine-induced side effects, such as respiratory depression and itching. Nalbuphine has been used effectively for patients undergoing Caesarean sections. However, the effectiveness of nalbuphine in the pediatric population has not been investigated. We want to determine the efficacy of nalbuphine in the treatment of itching after morphine for postoperative pain relief. We will use a novel method to measure the effect of the treatment using an intensity scale before and after the drug, to determine the intensity difference.
NCT00499746 The Discriminative Effects of Tramadol in Humans Completed National Institute on Drug Abuse (NIDA) Phase 1/Phase 2 This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram. It has effects similar to morphine, and it may also have effects similar to other drugs like stimulants. The doses of tramadol used in this study are higher than those generally used for the treatment of pain. To be in this study a participant must be a user of opioids (drugs like heroin) and stimulants (drugs like cocaine), but cannot be addicted to either. The person must be between 21-55 years old, and generally healthy. Up to 12 people will take part in this study.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Nalbuphine Hydrochloride

Condition Name

Condition Name for Nalbuphine Hydrochloride
Intervention Trials
Postoperative Pain 5
Pain 4
Uremic Pruritus 3
Surgery 3
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Condition MeSH

Condition MeSH for Nalbuphine Hydrochloride
Intervention Trials
Pain, Postoperative 9
Pruritus 7
Prurigo 3
Neurodermatitis 3
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Clinical Trial Locations for Nalbuphine Hydrochloride

Trials by Country

Trials by Country for Nalbuphine Hydrochloride
Location Trials
United States 66
Egypt 7
Taiwan 6
China 3
France 3
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Trials by US State

Trials by US State for Nalbuphine Hydrochloride
Location Trials
California 5
Ohio 4
North Carolina 4
New York 4
Pennsylvania 4
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Clinical Trial Progress for Nalbuphine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Nalbuphine Hydrochloride
Clinical Trial Phase Trials
Phase 4 7
Phase 3 4
Phase 2/Phase 3 7
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Clinical Trial Status

Clinical Trial Status for Nalbuphine Hydrochloride
Clinical Trial Phase Trials
Completed 13
Recruiting 10
Not yet recruiting 7
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Clinical Trial Sponsors for Nalbuphine Hydrochloride

Sponsor Name

Sponsor Name for Nalbuphine Hydrochloride
Sponsor Trials
Assiut University 7
Trevi Therapeutics 6
Tri-Service General Hospital 2
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Sponsor Type

Sponsor Type for Nalbuphine Hydrochloride
Sponsor Trials
Other 37
Industry 10
NIH 1
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Serving hundreds of leading biopharmaceutical companies globally:

US Army
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McKinsey
Boehringer Ingelheim
Julphar
Chubb
Fish and Richardson
Covington

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