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Last Updated: October 20, 2019

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CLINICAL TRIALS PROFILE FOR NALBUPHINE

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Clinical Trials for Nalbuphine

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00155233 Interaction Between Nalbuphine and Morphine in PCA Unknown status National Taiwan University Hospital Phase 4 2005-01-01 1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. This study was designed to investigate the interaction between nalbuphine and morphine
NCT00200564 Ketamine and Postoperative Analgesia in Children Unknown status Nantes University Hospital Phase 4 2004-02-01 The benefit of small doses of ketamine has been demonstrated for postoperative analgesia in adults but remains unproved in children. The investigators' purpose is to evaluate the effects of continuous intravenous small doses of ketamine versus placebo to improve the quality of postoperative analgesia in children (6 months to 6 years of age). Caudal anesthesia is performed for intraoperative analgesia and all children receive paracetamol, a non-steroidal anti-inflammatory and continuous intravenous nalbuphine.
NCT00323154 Nalbuphine for the Treatment of Opioid Induced Pruritus in Children Completed University of British Columbia Phase 3 2004-03-01 Itching is a frequent and disturbing side effect of the use of pain medication such as morphine. In the post-operative period, it can be more distressing to pediatric patients than their pain. The current first line treatment, an antihistamine (Benadryl), has a low efficacy. This treatment causes sleepiness and may be dangerous when used in combination with other drugs. Nalbuphine has analgesic properties similar to morphine as well as the ability to reverse some morphine-induced side effects, such as respiratory depression and itching. Nalbuphine has been used effectively for patients undergoing Caesarean sections. However, the effectiveness of nalbuphine in the pediatric population has not been investigated. We want to determine the efficacy of nalbuphine in the treatment of itching after morphine for postoperative pain relief. We will use a novel method to measure the effect of the treatment using an intensity scale before and after the drug, to determine the intensity difference.
NCT00499746 The Discriminative Effects of Tramadol in Humans Completed National Institute on Drug Abuse (NIDA) Phase 1/Phase 2 2007-11-01 This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram. It has effects similar to morphine, and it may also have effects similar to other drugs like stimulants. The doses of tramadol used in this study are higher than those generally used for the treatment of pain. To be in this study a participant must be a user of opioids (drugs like heroin) and stimulants (drugs like cocaine), but cannot be addicted to either. The person must be between 21-55 years old, and generally healthy. Up to 12 people will take part in this study.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Nalbuphine

Condition Name

Condition Name for Nalbuphine
Intervention Trials
Postoperative Pain 6
Pain 5
Surgery 3
Nalbuphine 3
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Condition MeSH

Condition MeSH for Nalbuphine
Intervention Trials
Pain, Postoperative 11
Pruritus 7
Prurigo 3
Neurodermatitis 3
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Clinical Trial Locations for Nalbuphine

Trials by Country

Trials by Country for Nalbuphine
Location Trials
United States 67
Egypt 12
Taiwan 8
China 4
Canada 3
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Trials by US State

Trials by US State for Nalbuphine
Location Trials
California 5
Ohio 4
North Carolina 4
New York 4
Pennsylvania 4
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Clinical Trial Progress for Nalbuphine

Clinical Trial Phase

Clinical Trial Phase for Nalbuphine
Clinical Trial Phase Trials
Phase 4 11
Phase 3 5
Phase 2/Phase 3 7
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Clinical Trial Status

Clinical Trial Status for Nalbuphine
Clinical Trial Phase Trials
Completed 15
Recruiting 13
Not yet recruiting 12
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Clinical Trial Sponsors for Nalbuphine

Sponsor Name

Sponsor Name for Nalbuphine
Sponsor Trials
Trevi Therapeutics 9
Assiut University 8
Cairo University 3
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Sponsor Type

Sponsor Type for Nalbuphine
Sponsor Trials
Other 51
Industry 15
NIH 1
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