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Last Updated: December 12, 2024

CLINICAL TRIALS PROFILE FOR NALBUPHINE


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All Clinical Trials for Nalbuphine

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00155233 ↗ Interaction Between Nalbuphine and Morphine in PCA Unknown status National Taiwan University Hospital Phase 4 2005-01-01 1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. This study was designed to investigate the interaction between nalbuphine and morphine
NCT00200564 ↗ Ketamine and Postoperative Analgesia in Children Unknown status Nantes University Hospital Phase 4 2004-02-01 The benefit of small doses of ketamine has been demonstrated for postoperative analgesia in adults but remains unproved in children. The investigators' purpose is to evaluate the effects of continuous intravenous small doses of ketamine versus placebo to improve the quality of postoperative analgesia in children (6 months to 6 years of age). Caudal anesthesia is performed for intraoperative analgesia and all children receive paracetamol, a non-steroidal anti-inflammatory and continuous intravenous nalbuphine.
NCT00323154 ↗ Nalbuphine for the Treatment of Opioid Induced Pruritus in Children Completed University of British Columbia Phase 3 2004-03-01 Itching is a frequent and disturbing side effect of the use of pain medication such as morphine. In the post-operative period, it can be more distressing to pediatric patients than their pain. The current first line treatment, an antihistamine (Benadryl), has a low efficacy. This treatment causes sleepiness and may be dangerous when used in combination with other drugs. Nalbuphine has analgesic properties similar to morphine as well as the ability to reverse some morphine-induced side effects, such as respiratory depression and itching. Nalbuphine has been used effectively for patients undergoing Caesarean sections. However, the effectiveness of nalbuphine in the pediatric population has not been investigated. We want to determine the efficacy of nalbuphine in the treatment of itching after morphine for postoperative pain relief. We will use a novel method to measure the effect of the treatment using an intensity scale before and after the drug, to determine the intensity difference.
NCT00499746 ↗ The Discriminative Effects of Tramadol in Humans Completed National Institute on Drug Abuse (NIDA) Phase 1/Phase 2 2007-11-01 This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram. It has effects similar to morphine, and it may also have effects similar to other drugs like stimulants. The doses of tramadol used in this study are higher than those generally used for the treatment of pain. To be in this study a participant must be a user of opioids (drugs like heroin) and stimulants (drugs like cocaine), but cannot be addicted to either. The person must be between 21-55 years old, and generally healthy. Up to 12 people will take part in this study.
NCT00707824 ↗ Epidural Nalbuphine for Postcesarean Epidural Morphine Induced Pruritus Completed Mahidol University Phase 4 2000-06-01 Can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?
NCT00716807 ↗ Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain Terminated University of California, San Francisco N/A 2008-01-01 Patients with chronic masticatory muscle pain (i.e., pain greater than three months) or patients with burning mouth syndrome participate in this study. The aim of the study is to compare the pain killing effectiveness of nalbuphine, a narcotic pain killer, administered with either placebo or naloxone, a drug used to treat opiate overdose. A second goal is to determine if there are sex differences in these two drug regimens. Drugs will be administered with single-use intranasal spray devices. All participants will receive two sprays (one spray per nostril). One of the two sprays will be nalbuphine (5 mg). The other spray will be naloxone in half the participants and placebo in the other half.
NCT00874172 ↗ Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic Strategy Completed Assistance Publique - Hôpitaux de Paris N/A 2009-10-01 Quality of life of adult patients with sickle cell disease is deeply impaired by severe adverse medical events that inadvertently occur throughout their time life. Indeed, patients not presenting a life threatening condition often present to the emergency department with sickle cell disease crisis related pain. Currently, the effectiveness of specific analgesic strategies for treating sickle cell disease crisis related pain are mostly based on acetaminophen and opioid derivates combination along with oxygen delivery. Those strategies are effective but may last up to half an hour to obtain pain relief. This delay mostly depends on the availability of venous access and on individual patient response to treatment. Nitrous oxide is a volatile efficient analgesic therapy that has been repeatedly shown to allow rapid analgesia in the emergency department setting. The investigators hypothesise that a new analgesic strategy (rapid optimized analgesic strategy) including nitrous oxide and nefopam would be as safe and more rapidly effective than current analgesic strategy.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Nalbuphine

Condition Name

Condition Name for Nalbuphine
Intervention Trials
Pain, Postoperative 10
Postoperative Pain 10
Pain 6
Post Operative Pain 5
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Condition MeSH

Condition MeSH for Nalbuphine
Intervention Trials
Pain, Postoperative 34
Pruritus 9
Vomiting 6
Emergence Delirium 6
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Clinical Trial Locations for Nalbuphine

Trials by Country

Trials by Country for Nalbuphine
Location Trials
United States 86
Egypt 34
China 23
Taiwan 15
United Kingdom 12
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Trials by US State

Trials by US State for Nalbuphine
Location Trials
California 7
Ohio 5
Texas 4
Pennsylvania 4
North Carolina 4
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Clinical Trial Progress for Nalbuphine

Clinical Trial Phase

Clinical Trial Phase for Nalbuphine
Clinical Trial Phase Trials
Phase 4 32
Phase 3 8
Phase 2/Phase 3 10
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Clinical Trial Status

Clinical Trial Status for Nalbuphine
Clinical Trial Phase Trials
Completed 47
Recruiting 21
Not yet recruiting 19
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Clinical Trial Sponsors for Nalbuphine

Sponsor Name

Sponsor Name for Nalbuphine
Sponsor Trials
Assiut University 14
Trevi Therapeutics 10
Ain Shams University 8
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Sponsor Type

Sponsor Type for Nalbuphine
Sponsor Trials
Other 106
Industry 19
NIH 1
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