Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury
Not yet recruiting
Randy Trumbower, PT, PhD
Phase 1/Phase 2
2022-06-01
Breathing brief, moderate bouts of low oxygen (acute intermittent hypoxia, AIH) trigger
spinal plasticity and improve walking function after spinal cord injury (SCI). However,
extracellular adenosine accumulates during hypoxia exposures and may undermine the efficacy
of AIH training-induced walking recovery. The goal of the study is to understand how caffeine
may augment the effects of AIH training on walking recovery and spinal plasticity (the
ability of the nervous system to strengthen neural pathways based on new experiences)
following SCI.
The purpose of this research study is to determine the effects of a medication,
istradefylline, in conjunction with breathing air with reduced oxygen for short periods of
time (called acute intermittent hypoxia, or AIH), on breathing. This project will study
breathing in people with amyotrophic lateral sclerosis (ALS) and unaffected, age-matched
adults. Istradefylline is prescribed to increase movement in people with other neuromuscular
conditions. A recently completed study found that people with ALS took deeper breaths, 60
minutes after using AIH.
The purpose of this research study is to determine the effects of a medication,
istradefylline, in conjunction with breathing air with reduced oxygen for short periods of
time (called acute intermittent hypoxia, or AIH), on breathing. This project will study
breathing in people with amyotrophic lateral sclerosis (ALS) and unaffected, age-matched
adults. Istradefylline is prescribed to increase movement in people with other neuromuscular
conditions. A recently completed study found that people with ALS took deeper breaths, 60
minutes after using AIH.
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