Chemotherapy Plus Hormone Therapy Versus Androgen Suppression in Treating Patients With Metastatic or Unresectable Prostate Cancer
Completed
National Cancer Institute (NCI)
Phase 3
1996-08-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining hormone therapy with chemotherapy and androgen
suppression may kill more tumor cells. It is not yet known which treatment regimen is more
effective for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy plus hormone
therapy versus androgen suppression alone as initial therapy in patients with prostate cancer
that is metastatic or that cannot be removed surgically.
Chemotherapy Plus Hormone Therapy Versus Androgen Suppression in Treating Patients With Metastatic or Unresectable Prostate Cancer
Completed
M.D. Anderson Cancer Center
Phase 3
1996-08-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining hormone therapy with chemotherapy and androgen
suppression may kill more tumor cells. It is not yet known which treatment regimen is more
effective for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy plus hormone
therapy versus androgen suppression alone as initial therapy in patients with prostate cancer
that is metastatic or that cannot be removed surgically.
Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer
Terminated
National Cancer Institute (NCI)
Phase 1
2007-09-01
This phase I trial is studying the side effects and best dose of temsirolimus when given
together with hormone therapy in treating patients with relapsed prostate cancer. Androgens
can cause the growth of prostate cancer cells. Hormone therapy may fight prostate cancer by
lowering the amount of androgens the body makes. Temsirolimus may stop the growth of tumor
cells by blocking some of the enzymes needed for cell growth. Giving hormone therapy together
with temsirolimus may kill more tumor cells
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