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Generated: October 15, 2018

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CLINICAL TRIALS PROFILE FOR NEXAVAR

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Clinical Trials for NEXAVAR

Trial ID Title Status Sponsor Phase Summary
NCT00064350 Sorafenib in Treating Patients With Refractory Non-Small Cell Lung Cancer Completed National Cancer Institute (NCI) Phase 2 RATIONALE: Preclinical studies indicate that sorafenib is a potent inhibitor of Raf kinase in vitro and in vivo, with significant dose-dependent, anti-tumor activity in four different human tumor types including colon, pancreatic, lung, and ovarian. This activity was cytostatic in nature and was maintained if dosing was continued. That is, tumor growth is suspended while the drug is administered but returns to baseline rates when the agent is withdrawn. Therefore, the optimal schedule will be an uninterrupted one. To assess the activity of sorafenib in a timely manner and with a meaningful interpretation, a randomized discontinuation design was adopted in the present trial, conducted in a population who were potentially sensitive to sorafenib. PURPOSE: This randomized phase II trial is studying sorafenib to see how well it works compared to placebo in treating patients with refractory non-small cell lung cancer.
NCT00064350 Sorafenib in Treating Patients With Refractory Non-Small Cell Lung Cancer Completed Eastern Cooperative Oncology Group Phase 2 RATIONALE: Preclinical studies indicate that sorafenib is a potent inhibitor of Raf kinase in vitro and in vivo, with significant dose-dependent, anti-tumor activity in four different human tumor types including colon, pancreatic, lung, and ovarian. This activity was cytostatic in nature and was maintained if dosing was continued. That is, tumor growth is suspended while the drug is administered but returns to baseline rates when the agent is withdrawn. Therefore, the optimal schedule will be an uninterrupted one. To assess the activity of sorafenib in a timely manner and with a meaningful interpretation, a randomized discontinuation design was adopted in the present trial, conducted in a population who were potentially sensitive to sorafenib. PURPOSE: This randomized phase II trial is studying sorafenib to see how well it works compared to placebo in treating patients with refractory non-small cell lung cancer.
NCT00079612 Study of Nexavar (Sorafenib, BAY 43-9006) in Patients With Advanced Refractory Cancer Completed Onyx Pharmaceuticals Phase 2 The purpose of the study is to: - Find out if BAY 43-9006 prevents the growth of tumors - For patients who have stable cancer status after 3 months of treatment if it is safer and/or more effective to continue to give BAY 43-9006 or to stop giving BAY 43-9006 at that time. - Find out how long the effect of BAY 43-9006 is on tumors. To assess the safety of BAY 43-9006 (sorafenib) in the treatment of advanced refractory cancers. - Measure the amount of BAY 43-9006 and some of its targets in the blood stream in some patients.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for NEXAVAR

Condition Name

Condition Name for NEXAVAR
Intervention Trials
Hepatocellular Carcinoma 33
Carcinoma, Renal Cell 18
Carcinoma, Hepatocellular 14
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Condition MeSH

Condition MeSH for NEXAVAR
Intervention Trials
Carcinoma 108
Carcinoma, Hepatocellular 72
Carcinoma, Renal Cell 41
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Clinical Trial Locations for NEXAVAR

Trials by Country

Trials by Country for NEXAVAR
Location Trials
United States 934
Germany 49
Canada 48
Japan 31
Korea, Republic of 24
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Trials by US State

Trials by US State for NEXAVAR
Location Trials
Texas 51
California 46
New York 42
Florida 39
Pennsylvania 38
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Clinical Trial Progress for NEXAVAR

Clinical Trial Phase

Clinical Trial Phase for NEXAVAR
Clinical Trial Phase Trials
Phase 4 5
Phase 3 17
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for NEXAVAR
Clinical Trial Phase Trials
Completed 126
Recruiting 48
Active, not recruiting 38
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Clinical Trial Sponsors for NEXAVAR

Sponsor Name

Sponsor Name for NEXAVAR
Sponsor Trials
National Cancer Institute (NCI) 94
Bayer 85
M.D. Anderson Cancer Center 15
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Sponsor Type

Sponsor Type for NEXAVAR
Sponsor Trials
Other 210
Industry 154
NIH 95
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Serving hundreds of leading biopharmaceutical companies globally:

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Fish and Richardson
Express Scripts
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Baxter
Moodys
Accenture

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