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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE


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All Clinical Trials for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00125931 ↗ Effects of Pentazocine on Manic Symptoms Completed Stanley Medical Research Institute Phase 2 2005-09-01 The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.
NCT00125931 ↗ Effects of Pentazocine on Manic Symptoms Completed Mclean Hospital Phase 2 2005-09-01 The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.
NCT02070718 ↗ Effects of a Kappa Agonist on Hot Flashes in Menopausal Women Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1 2013-01-01 Studies suggest that kappa agonists (KA) and peripherally restricted kappa agonists (PRKAs) may affect thermoregulation. This pilot study has the aim to establish proof of concept regarding efficacy of an oral kappa agonist (KA) for the treatment of menopausal hot flashes.
NCT02070718 ↗ Effects of a Kappa Agonist on Hot Flashes in Menopausal Women Completed National Center for Advancing Translational Science (NCATS) Phase 1 2013-01-01 Studies suggest that kappa agonists (KA) and peripherally restricted kappa agonists (PRKAs) may affect thermoregulation. This pilot study has the aim to establish proof of concept regarding efficacy of an oral kappa agonist (KA) for the treatment of menopausal hot flashes.
NCT02070718 ↗ Effects of a Kappa Agonist on Hot Flashes in Menopausal Women Completed National Center for Complementary and Integrative Health (NCCIH) Phase 1 2013-01-01 Studies suggest that kappa agonists (KA) and peripherally restricted kappa agonists (PRKAs) may affect thermoregulation. This pilot study has the aim to establish proof of concept regarding efficacy of an oral kappa agonist (KA) for the treatment of menopausal hot flashes.
NCT02070718 ↗ Effects of a Kappa Agonist on Hot Flashes in Menopausal Women Completed National Institute on Aging (NIA) Phase 1 2013-01-01 Studies suggest that kappa agonists (KA) and peripherally restricted kappa agonists (PRKAs) may affect thermoregulation. This pilot study has the aim to establish proof of concept regarding efficacy of an oral kappa agonist (KA) for the treatment of menopausal hot flashes.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE

Condition Name

Condition Name for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Intervention Trials
Bipolar Disorder 1
Treatment of Menopausal Hot Flashes 1
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Condition MeSH

Condition MeSH for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Intervention Trials
Hot Flashes 1
Bipolar Disorder 1
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Clinical Trial Locations for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE

Trials by Country

Trials by Country for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Location Trials
United States 1
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Trials by US State

Trials by US State for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Location Trials
Washington 1
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Clinical Trial Progress for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 2 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Clinical Trial Phase Trials
Completed 2
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Clinical Trial Sponsors for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE

Sponsor Name

Sponsor Name for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Sponsor Trials
University of Washington 1
Stanley Medical Research Institute 1
Mclean Hospital 1
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Sponsor Type

Sponsor Type for NALOXONE HYDROCHLORIDE; PENTAZOCINE HYDROCHLORIDE
Sponsor Trials
NIH 5
Other 4
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