CLINICAL TRIALS PROFILE FOR MOXIDECTIN
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All Clinical Trials for Moxidectin
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00300768 ↗ | Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection | Completed | World Health Organization | Phase 2 | 2006-09-01 | The primary purpose of this study is to determine the safety and tolerability of moxidectin in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to determine whether it is safe enough to expose a number of subjects sufficient for obtaining statistically significant data on the safety and efficacy of moxidectin relative to ivermectin. Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial indication of the efficacy in terms of long term effect on skin microfilaria levels and an indication of the effect on the macrofilaria that may underlie the effect on skin microfilaria levels. |
| NCT00300768 ↗ | Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection | Completed | Medicines Development for Global Health | Phase 2 | 2006-09-01 | The primary purpose of this study is to determine the safety and tolerability of moxidectin in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to determine whether it is safe enough to expose a number of subjects sufficient for obtaining statistically significant data on the safety and efficacy of moxidectin relative to ivermectin. Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial indication of the efficacy in terms of long term effect on skin microfilaria levels and an indication of the effect on the macrofilaria that may underlie the effect on skin microfilaria levels. |
| NCT00736697 ↗ | Study Evaluating The Effect Of High-Fat Meal On Bioavailability And Pharmacokinetics Of Single Dose Of Moxidectin | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 1 | 2008-11-01 | The primary objective of this study is to assess the effect of a high-fat meal (breakfast) on the concentrations of moxidectin measured in the blood after a single oral administration in healthy subjects. |
| NCT00751764 ↗ | Study Evaluating The Excretion Of Moxidectin Into The Breast Milk Of Lactating, Non-Breastfeeding Women | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 1 | 2008-11-01 | The purpose of this study is to evaluate the extent of moxidectin transfer into the breast milk of lactating women and to provide the initial pharmacokinetic and safety profile of moxidectin in lactating women. |
| NCT00790998 ↗ | Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection | Completed | World Health Organization | Phase 3 | 2009-04-01 | This is a Phase 3 study comparing the efficacy, safety and tolerability of moxidectin and ivermectin in subjects infected with Onchocerca volvulus, which is the parasite that causes river blindness. Subjects participating in the study will be randomly assigned (by a 2 to1 ratio) to receive one orally-administered dose of either moxidectin or ivermectin. |
| NCT00790998 ↗ | Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection | Completed | Medicines Development for Global Health | Phase 3 | 2009-04-01 | This is a Phase 3 study comparing the efficacy, safety and tolerability of moxidectin and ivermectin in subjects infected with Onchocerca volvulus, which is the parasite that causes river blindness. Subjects participating in the study will be randomly assigned (by a 2 to1 ratio) to receive one orally-administered dose of either moxidectin or ivermectin. |
| NCT00856362 ↗ | Study Evaluating The Co-Administration Of Moxidectin And Midazolam In Healthy Subjects | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 1 | 2009-04-01 | The purpose of this study is to evaluate the effect of single doses of midazolam on the plasma concentration of a single dose of moxidectin in healthy young adult subjects, and to assess the safety of co-administration of moxidectin and midazolam. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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