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Last Updated: January 26, 2023

CLINICAL TRIALS PROFILE FOR MOXIDECTIN


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All Clinical Trials for Moxidectin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00300768 ↗ Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed World Health Organization Phase 2 2006-09-01 The primary purpose of this study is to determine the safety and tolerability of moxidectin in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to determine whether it is safe enough to expose a number of subjects sufficient for obtaining statistically significant data on the safety and efficacy of moxidectin relative to ivermectin. Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial indication of the efficacy in terms of long term effect on skin microfilaria levels and an indication of the effect on the macrofilaria that may underlie the effect on skin microfilaria levels.
NCT00300768 ↗ Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed Medicines Development for Global Health Phase 2 2006-09-01 The primary purpose of this study is to determine the safety and tolerability of moxidectin in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to determine whether it is safe enough to expose a number of subjects sufficient for obtaining statistically significant data on the safety and efficacy of moxidectin relative to ivermectin. Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial indication of the efficacy in terms of long term effect on skin microfilaria levels and an indication of the effect on the macrofilaria that may underlie the effect on skin microfilaria levels.
NCT00736697 ↗ Study Evaluating The Effect Of High-Fat Meal On Bioavailability And Pharmacokinetics Of Single Dose Of Moxidectin Completed Wyeth is now a wholly owned subsidiary of Pfizer Phase 1 2008-11-01 The primary objective of this study is to assess the effect of a high-fat meal (breakfast) on the concentrations of moxidectin measured in the blood after a single oral administration in healthy subjects.
NCT00751764 ↗ Study Evaluating The Excretion Of Moxidectin Into The Breast Milk Of Lactating, Non-Breastfeeding Women Completed Wyeth is now a wholly owned subsidiary of Pfizer Phase 1 2008-11-01 The purpose of this study is to evaluate the extent of moxidectin transfer into the breast milk of lactating women and to provide the initial pharmacokinetic and safety profile of moxidectin in lactating women.
NCT00790998 ↗ Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed World Health Organization Phase 3 2009-04-01 This is a Phase 3 study comparing the efficacy, safety and tolerability of moxidectin and ivermectin in subjects infected with Onchocerca volvulus, which is the parasite that causes river blindness. Subjects participating in the study will be randomly assigned (by a 2 to1 ratio) to receive one orally-administered dose of either moxidectin or ivermectin.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Moxidectin

Condition Name

Condition Name for Moxidectin
Intervention Trials
Onchocerciasis 7
Hookworm Infections 2
Infection 2
Ascariasis 2
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Condition MeSH

Condition MeSH for Moxidectin
Intervention Trials
Onchocerciasis 8
Trichuriasis 3
Ascariasis 2
Ancylostomiasis 2
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Clinical Trial Locations for Moxidectin

Trials by Country

Trials by Country for Moxidectin
Location Trials
Congo, The Democratic Republic of the 4
Ghana 3
Cambodia 2
France 2
Côte D'Ivoire 2
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Trials by US State

Trials by US State for Moxidectin
Location Trials
Wisconsin 1
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Clinical Trial Progress for Moxidectin

Clinical Trial Phase

Clinical Trial Phase for Moxidectin
Clinical Trial Phase Trials
Phase 4 1
Phase 3 6
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Moxidectin
Clinical Trial Phase Trials
Completed 8
Recruiting 4
Withdrawn 2
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Clinical Trial Sponsors for Moxidectin

Sponsor Name

Sponsor Name for Moxidectin
Sponsor Trials
Medicines Development for Global Health 7
World Health Organization 5
Medicines Development Limited 4
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Sponsor Type

Sponsor Type for Moxidectin
Sponsor Trials
Other 33
Industry 4
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AstraZeneca
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