Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
Completed
Ionis Pharmaceuticals, Inc.
Phase 2
2006-07-01
This study will assess what, if any, effect that ISIS 301012 (mipomersen) has on liver
triglyceride content in multiple groups of subjects with varying degrees of risk for hepatic
steatosis. In order to enroll subject groups with varying degrees of risk, the study has
included multiple cohorts (Cohorts A-G). Additions and removal of cohorts has been
accomplished with protocol amendments.
Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
Completed
Kastle Therapeutics, LLC
Phase 2
2006-07-01
This study will assess what, if any, effect that ISIS 301012 (mipomersen) has on liver
triglyceride content in multiple groups of subjects with varying degrees of risk for hepatic
steatosis. In order to enroll subject groups with varying degrees of risk, the study has
included multiple cohorts (Cohorts A-G). Additions and removal of cohorts has been
accomplished with protocol amendments.
Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia
Completed
Ionis Pharmaceuticals, Inc.
Phase 2
2007-05-01
The purpose of this study is to evaluate the safety and efficacy of extended dosing of
mipomersen in patients with familial hypercholesterolemia on lipid-lowering therapy who have
completed either the 301012-CS8 (NCT00280995) or 301012-CS9 (NCT00281008) clinical drug
trials.
Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia
Completed
Kastle Therapeutics, LLC
Phase 2
2007-05-01
The purpose of this study is to evaluate the safety and efficacy of extended dosing of
mipomersen in patients with familial hypercholesterolemia on lipid-lowering therapy who have
completed either the 301012-CS8 (NCT00280995) or 301012-CS9 (NCT00281008) clinical drug
trials.
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