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Generated: December 13, 2018

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CLINICAL TRIALS PROFILE FOR MIFEPREX

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Clinical Trials for Mifeprex

Trial ID Title Status Sponsor Phase Summary
NCT00352911 Antiviral Activity and Safety of Mifepristone at 2 Doses in HIV-1 Infected Subjects Completed VGX Pharmaceuticals, LLC Phase 2 The objective of the study is to determine whether mifepristone (VGX-410) has anti-HIV-1 activity at doses of either 300 mg or 600 mg per day after oral administration for 14 days at each dose level.
NCT01224509 The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors Terminated University of Southern California N/A The purpose of this study is to determine the effect of mifepristone on the expression of three cervical EP3 receptor isoforms (EP3-2, EP3-3 and EP3-6) in pregnant women ≤63 days gestational age.
NCT01333098 Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders Completed Eric Lenze Phase 1/Phase 2 This study seeks to develop and test a novel, mechanistic treatment for mitigating cognitive impairment in older adults with anxiety disorders. Anxiety disorders are common, severe, and disabling in older adults. One particularly impairing aspect of late-life anxiety disorders is cognitive impairment: impairments in memory and executive function cause disability, impede treatment response to psychotherapy, may lead to dementia, and are not corrected by standard anti-anxiety treatments. This pilot study will test the glucocorticoid antagonist, mifepristone, for cognitive impairment in late-life anxiety disorders. Mifepristone blocks the effects of elevated cortisol levels on glucocorticoid receptors in the brain; it has been studied preliminarily in various neuropsychiatric disorders, such as psychotic depression and bipolar disorder, with well-documented safety and tolerability.
NCT01436279 Mifepristone Versus Osmotic Dilator Insertion for Cervical Preparation Prior to Surgical Abortion at 15-18 Weeks Completed Society of Family Planning Phase 3 In this study the investigators plan to compare mifepristone and misoprostol use to osmotic dilator use for cervical preparation for 15-18 week surgical abortion. Mifepristone would be given 24 hours prior to abortion, and misoprostol 400 mcg would be administered buccally 2 hours prior to abortion. Osmotic dilators are the method currently used in our institution, and are placed 24 hours prior to abortion. The primary outcome will be the length of the procedure. Secondary outcomes will include amount of dilation achieved, ease of procedure, participant's assessment of discomfort after mifepristone or dilators, discomfort during the abortion procedure, acceptability to participants, and acceptability to staff.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Mifeprex

Condition Name

Condition Name for Mifeprex
Intervention Trials
Legally Induced Abortion Without Mention of Complication 3
Stage IV Breast Cancer 2
Stage IIIC Breast Cancer 2
Stage IIIB Breast Cancer 2
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Condition MeSH

Condition MeSH for Mifeprex
Intervention Trials
Breast Neoplasms 3
Anxiety Disorders 3
Disease 2
Breast Neoplasms, Male 2
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Clinical Trial Locations for Mifeprex

Trials by Country

Trials by Country for Mifeprex
Location Trials
United States 39
Nepal 1
Armenia 1
Uzbekistan 1
Tunisia 1
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Trials by US State

Trials by US State for Mifeprex
Location Trials
California 8
Illinois 6
New York 5
Massachusetts 4
Pennsylvania 3
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Clinical Trial Progress for Mifeprex

Clinical Trial Phase

Clinical Trial Phase for Mifeprex
Clinical Trial Phase Trials
Phase 4 6
Phase 3 2
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Mifeprex
Clinical Trial Phase Trials
Completed 10
Recruiting 6
Active, not recruiting 3
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Clinical Trial Sponsors for Mifeprex

Sponsor Name

Sponsor Name for Mifeprex
Sponsor Trials
University of Chicago 4
Gynuity Health Projects 4
Stanford University 2
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Sponsor Type

Sponsor Type for Mifeprex
Sponsor Trials
Other 31
NIH 4
U.S. Fed 3
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