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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR METOCLOPRAMIDE HYDROCHLORIDE


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All Clinical Trials for Metoclopramide Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00003213 ↗ Drugs to Reduce the Side Effects of Chemotherapy Completed Swiss Group for Clinical Cancer Research Phase 3 1996-05-01 RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients treated with chemotherapy. It is not known whether receiving dexamethasone with granisetron is more effective than receiving dexamethasone with metoclopramide for reducing the side effects of chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of dexamethasone with either granisetron or metoclopramide in patients treated with chemotherapy.
NCT00008736 ↗ Electrogastrography (EGC) in Premature Infants With Feeding Intolerance Completed Children's Hospital of Philadelphia Phase 2 1969-12-31 Serial EGC measurements in premature infants attempting to correlate EGC measurements with signs of feeding intolerance and response to metoclopramide therapy.
NCT00008736 ↗ Electrogastrography (EGC) in Premature Infants With Feeding Intolerance Completed National Center for Research Resources (NCRR) Phase 2 1969-12-31 Serial EGC measurements in premature infants attempting to correlate EGC measurements with signs of feeding intolerance and response to metoclopramide therapy.
NCT00120653 ↗ Metoclopramide to Treat Anemia in Patients With Myelodysplastic Syndrome (MDS) Withdrawn National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2005-07-14 This study will determine whether the medication metoclopramide can improve red blood counts in people who have myelodysplastic syndrome (MDS). MDS is thought to affect blood stem cells, which can result in low levels of red blood cells-that is, anemia-as well as low white blood cell and platelet counts. Patients with MDS are at risk for infection, spontaneous bleeding, and possible progression to leukemia, a cancer of bone marrow. Although bone marrow can produce some blood cells, this production can be decreased in patients with MDS. The definitive way to treat MDS is stem cell transplantation, but serious complications and a high risk of death make it unsuitable for patients older than age 60 or those who do not have a matched sibling donor. However, scientists have noted improvement in anemia by using metoclopramide, an inexpensive, commonly used medication that does not have many negative side effects. This study will evaluate the safety and effectiveness of that medicine for patients with MDS. Patients ages 18 to 72 whose MDS would require low-intensity treatment-for example, with growth factor and transfusions-and who are not pregnant or breastfeeding may be eligible for this study. There will be about 60 participants. Screening tests include a complete physical examination and medical history, during which patients will provide a list of current medications or supplements they are taking. There will be a collection of about 4 tablespoons of blood for analysis of blood counts as well as liver and kidney function. Patients may also undergo a magnetic resonance imaging (MRI) scan of their brain, but the procedure is optional. During the MRI, they will lie on a table that will slide into the enclosed tunnel of the scanner. The MRI takes about 20 to 30 minutes, and patients will be asked to lie as still as possible. There will also be a bone marrow biopsy, if patients have not had one done within 4 weeks of the start of this study. Eligible patients will take a 10 mg dose of metoclopramide by mouth, three times a day, for 20 weeks. They will be given a 4-week supply, which will be renewed monthly at each treatment visit. It is essential that patients be seen at NIH during the first, third, and fifth months of the study. Visits made in the meantime, at the second and fourth months, may be done at the office of their doctors who have referred them for the study, or at NIH. During the treatment visits, patients will be asked to update their medical history, health conditions, and use of medications or herbal supplements. There will also be a collection of about 1 tablespoon of blood for laboratory tests. Patients will be asked to make a similar follow-up visit 1 month after they stop taking metoclopramide, so that the response to treatment can be evaluated. The use of metoclopramide may cause some people to feel dizzy, lightheaded, tired, or less alert than they are normally. For the first 24 to 48 hours, patients should be cautious when driving, using machinery, or performing hazardous activities. This medicine will add to the effects of alcohol and other central nervous system depressants-such as medicines for allergies and colds, tranquilizers, and prescription pain relievers. Patients need to check with the research team before taking any of those types of medicines, as well as herbal supplements, while using metoclopramide. This study may or may not have a direct benefit for participants. For some, the drug may improve red blood cell counts and decrease the need for red cell transfusions. Knowledge gained in the study may help people in the future.
NCT00122278 ↗ Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines Completed Montefiore Medical Center Phase 3 2005-07-01 Migraines are a specific type of headache that frequently recur and are very painful. Although there are many medications that are effective against migraines, none of these medications cure 100% of migraines. Another problem with migraines is that although many times they get better after intravenous (IV) treatment in the emergency room (ER), about 1/3 of the time migraines recur the next day. The purpose of this research project is to see if adding a medication called dexamethasone to standard ER therapy will help patients get better quicker and stay pain-free more often than if they receive placebo.
NCT00130026 ↗ Caffeine in the Prevention of Post-operative Nausea and Vomiting Completed Beth Israel Deaconess Medical Center N/A 2005-03-01 The objective of this study is to determine if caffeine 500 mg intravenously is efficacious when added to standard anti-emetic prophylaxis in the prevention of post-operative nausea and vomiting (PONV) in patients undergoing ambulatory surgery under general anesthesia.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Metoclopramide Hydrochloride

Condition Name

Condition Name for Metoclopramide Hydrochloride
Intervention Trials
Nausea 17
Migraine 14
Postoperative Nausea and Vomiting 14
Vomiting 9
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Condition MeSH

Condition MeSH for Metoclopramide Hydrochloride
Intervention Trials
Vomiting 51
Nausea 43
Migraine Disorders 31
Postoperative Nausea and Vomiting 29
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Clinical Trial Locations for Metoclopramide Hydrochloride

Trials by Country

Trials by Country for Metoclopramide Hydrochloride
Location Trials
United States 219
Egypt 34
Canada 20
Australia 16
Turkey 12
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Trials by US State

Trials by US State for Metoclopramide Hydrochloride
Location Trials
New York 28
Pennsylvania 15
Texas 13
Illinois 11
Ohio 10
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Clinical Trial Progress for Metoclopramide Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Metoclopramide Hydrochloride
Clinical Trial Phase Trials
Phase 4 89
Phase 3 36
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for Metoclopramide Hydrochloride
Clinical Trial Phase Trials
Completed 138
Recruiting 33
Not yet recruiting 29
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Clinical Trial Sponsors for Metoclopramide Hydrochloride

Sponsor Name

Sponsor Name for Metoclopramide Hydrochloride
Sponsor Trials
Montefiore Medical Center 13
Assiut University 11
Cairo University 9
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Sponsor Type

Sponsor Type for Metoclopramide Hydrochloride
Sponsor Trials
Other 310
Industry 36
NIH 8
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