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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR METHOTREXATE

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Clinical Trials for Methotrexate

Trial ID Title Status Sponsor Phase Summary
NCT00000361 Autoimmunity in Inner Ear Disease Terminated National Institute on Deafness and Other Communication Disorders (NIDCD) Phase 3 The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive sensorineural hearing loss in both ears. This condition is called autoimmune inner ear disease (AIED), because it is thought that the hearing loss is triggered by an autoimmune process. Treatment attempts to suppress or control this process with powerful anti-inflammatory drugs. This is a Phase III, outpatient study. All study participants will be assigned to one of four different groups testing the experimental use of drugs. The study is scheduled to run for 18 months, with a minimum of 11 visits per participant.
NCT00000395 Antifolate Effectiveness in Arthritis Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 2 This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
NCT00000395 Antifolate Effectiveness in Arthritis Completed Office of Dietary Supplements (ODS) Phase 2 This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Methotrexate

Condition Name

Condition Name for Methotrexate
Intervention Trials
Rheumatoid Arthritis 409
Leukemia 197
Lymphoma 132
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Condition MeSH

Condition MeSH for Methotrexate
Intervention Trials
Arthritis 548
Arthritis, Rheumatoid 515
Leukemia 374
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Clinical Trial Locations for Methotrexate

Trials by Country

Trials by Country for Methotrexate
Location Trials
Canada 702
Hungary 96
Netherlands 89
South Africa 81
India 81
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Trials by US State

Trials by US State for Methotrexate
Location Trials
Texas 377
California 344
Pennsylvania 294
Florida 281
New York 278
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Clinical Trial Progress for Methotrexate

Clinical Trial Phase

Clinical Trial Phase for Methotrexate
Clinical Trial Phase Trials
Phase 4 184
Phase 3 442
Phase 2/Phase 3 46
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Clinical Trial Status

Clinical Trial Status for Methotrexate
Clinical Trial Phase Trials
Completed 818
Recruiting 326
Terminated 151
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Clinical Trial Sponsors for Methotrexate

Sponsor Name

Sponsor Name for Methotrexate
Sponsor Trials
National Cancer Institute (NCI) 283
M.D. Anderson Cancer Center 83
Hoffmann-La Roche 70
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Sponsor Type

Sponsor Type for Methotrexate
Sponsor Trials
Other 1572
Industry 827
NIH 365
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