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CLINICAL TRIALS PROFILE FOR METHAZOLAMIDE

All Clinical Trials for Methazolamide

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00257829	Improving Tumor Oxygenation in Cervical Cancer	Withdrawn	University of California, Irvine	Phase 2	2004-07-01	The Phenomenon of Tumor Hypoxia Many solid tumors are relatively resistant to treatment with ionizing radiation and certain chemotherapeutic agents such as anthracyclines that are affected adversely by acidic pH. These effects have primarily been attributed to the presence of hypoxic cells within the tumor. The relevance of hypoxia with respect to failure of radiotherapy to cure certain malignancies has had a chequered history. However, in recent years the evidence that hypoxia plays a central role in relative radioresistance has become more compelling. Since approximately two-thirds of all women suffering from cervical carcinoma receive radiation as a component of their therapy, an enhanced understanding of the interactions between hypoxia and radiation as a component of their therapy, an enhanced understanding of the interactions between hypoxia and radiation resistance is critical to improving outcome among those with cervical cancer.
NCT01587027	Safety Evaluation of Aminophylline and Methazolamide	Completed	Defense Advanced Research Projects Agency	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01587027	Safety Evaluation of Aminophylline and Methazolamide	Completed	University of Colorado, Denver	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01587027	Safety Evaluation of Aminophylline and Methazolamide	Completed	Poudre Valley Health System	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01702025	Rapid Acclimatization to Hypoxia at Altitude	Completed	Defense Advanced Research Projects Agency	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.
NCT01702025	Rapid Acclimatization to Hypoxia at Altitude	Completed	University of Colorado, Denver	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.
NCT01702025	Rapid Acclimatization to Hypoxia at Altitude	Completed	Colorado State University	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.
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