CLINICAL TRIALS PROFILE FOR METHADOSE

All Clinical Trials for Methadose

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	National Institute on Drug Abuse (NIDA)	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	Yale University	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	Baylor College of Medicine	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00573937 ↗	Methadone Versus Morphine for Cancer-Related Pain	Terminated	Mayo Clinic	Phase 2	2007-08-01	The purpose of this study is to compare methadone with morphine in the management of moderate to severe cancer pain.
NCT00726830 ↗	Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer	Terminated	National Cancer Institute (NCI)	N/A	2009-03-01	RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.
NCT00726830 ↗	Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer	Terminated	M.D. Anderson Cancer Center	N/A	2009-03-01	RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.
NCT00892606 ↗	Methadone Versus Morphine for Orthopedic Surgery Patients	Completed	University of Louisville	Phase 4	2009-01-01	The investigators propose to compare analgesia by methadone and ketamine with a combination of morphine and ketamine in orthopedic surgery patients with moderate to severe pain. The investigators hypothesize that when given with ketamine before surgical incision, methadone is more effective than morphine in reducing postoperative morphine consumption and reducing pain during movement.

Clinical Trial Conditions for Methadose

Condition Name

Condition Name for Methadose
Intervention	Trials
Pain	3
Stomatitis	1
Lymphoproliferative Disorder	1
Unspecified Adult Solid Tumor, Protocol Specific	1

Condition MeSH

Condition MeSH for Methadose
Intervention	Trials
Cancer Pain	2
Opioid-Related Disorders	2
Precancerous Conditions	1
Central Nervous System Neoplasms	1

Clinical Trial Locations for Methadose

Trials by Country

Trials by Country for Methadose
Location	Trials
United States	6
Canada	4

Trials by US State

Trials by US State for Methadose
Location	Trials
Texas	2
New York	1
Kentucky	1
South Carolina	1
Arizona	1

Clinical Trial Progress for Methadose

Clinical Trial Phase

Clinical Trial Phase for Methadose
Clinical Trial Phase	Trials
Phase 4	2
Phase 3	1
Phase 2	2

Clinical Trial Status

Clinical Trial Status for Methadose
Clinical Trial Phase	Trials
Completed	4
Terminated	2
Not yet recruiting	1

Clinical Trial Sponsors for Methadose

Sponsor Name

Sponsor Name for Methadose
Sponsor	Trials
National Cancer Institute (NCI)	2
M.D. Anderson Cancer Center	1
University of Louisville	1

Sponsor Type

Sponsor Type for Methadose
Sponsor	Trials
Other	11
NIH	3