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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR METFORMIN HYDROCHLORIDE; REPAGLINIDE

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Clinical Trials for Metformin Hydrochloride; Repaglinide

Trial ID Title Status Sponsor Phase Summary
NCT00118950 Effect of Metformin Versus Repaglinide Treatment in Non-Obese Type 2 Diabetic Patients Uncontrolled by Diet Completed Steno Diabetes Center Phase 4 Background: Metformin is the first drug of choice in obese patients with type-2 diabetes (T2DM) due to its antiglycaemic as well as its cardiovascular protective potentials. In non-obese T2DM patients insulin-secretagogues are empirically used as first choice. The aim of this study was to evaluate the effect of metformin versus an insulin-secretagogue, repaglinide on glycaemic regulation and non-glycaemic cardiovascular risk markers in non-obese patients with T2DM. Methods: Single-center, randomised, double-masked, double-dummy, cross-over-study of 96 non-obese (BMI ≤ 27 kg/m2) Caucasian T2DM-patients. After a one month run-in on diet-only treatment, patients were randomised to either repaglinide 2mg three times a day (t.i.d). followed by metformin 1g twice a day (b.i.d.) or vice versa each for a period of four months with a one month wash-out between interventions.
NCT00118963 Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes Completed Steno Diabetes Center Phase 4 Aim: The United Kingdom Prospective Diabetes Study (UKPDS) showed a reduction in cardiovascular events in obese patients with type-2-diabetes treated with metformin compared with other hypoglycaemic treatments with no difference in glycemic control between treatments. Non-obese patients with type-2-diabetes are usually treated with insulin-secretagogues or insulin when diet fails. Since non-obese patients with type-2-diabetes also carry a high risk of cardiovascular events, the use of metformin for this sub-group of patients might be more beneficial. Moreover, when insulin-treatment is initiated ongoing oral hypoglycaemic agents (OHA) are often continued, but in non-obese patients with type-2 diabetes little evidence exist for choosing the optimal class of OHA to be combined with insulin. The aim of the project is therefore to investigate the effect of metformin vs. an insulin-secretagogue (repaglinide) in combination with insulin on glycemic control and non-glycemic cardiovascular risk-factors in non-obese patients with type-2-diabetes, uncontrolled on diet alone. Methodology: Single-center, double-blind, double-dummy, randomized, parallel study involving 100 non-obese (BMI 27 kg/m2 or lower) patients with type-2-diabetes investigating the effect of treatment with metformin vs. repaglinide each in combination with biphasic insulin (Insulin-aspart 30/70, BIAsp30) for a period of 12 months.
NCT00399711 Effect of Repaglinide and Metformin Combination Tablet or Rosiglitazone and Metformin in Fixed Dose Combination on Blood Glucose Control in Patients With Type 2 Diabetes Completed Novo Nordisk A/S Phase 3 This trial is conducted in the United States of America (USA). This trial compares the changes in HbA1c after 26 weeks of repaglinide and metformin fixed dose combination tablet given as twice daily versus three times daily regimens or versus twice daily rosiglitazone and metformin fixed dose combination tablet in subjects with type 2 diabetes currently on monotherapy.
NCT00491725 Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs Completed Novo Nordisk A/S Phase 4 This trial is conducted in Asia. The aim of this trial is to evaluate the efficacy and safety of repaglinide and metformin combination therapy in Chinese subjects with type 2 diabetes inadequately controlled with OAD (oral anti-diabetic drugs).
NCT00568984 Efficacy and Safety of Repaglinide and Metformin Combined in Type 2 Diabetes Completed Novo Nordisk A/S Phase 4 This trial is conducted in Asia. The aim of this trial is to investigate the efficacy of blood glucose control with combination therapy of repaglinide and metformin compared to conventional treatment with a sulphonylurea or metformin in monotherapy in type 2 diabetes
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Metformin Hydrochloride; Repaglinide

Condition Name

Condition Name for Metformin Hydrochloride; Repaglinide
Intervention Trials
Diabetes Mellitus, Type 2 15
Diabetes 11
Type 2 Diabetes 2
Type 2 Diabetes Mellitus 1
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Condition MeSH

Condition MeSH for Metformin Hydrochloride; Repaglinide
Intervention Trials
Diabetes Mellitus, Type 2 18
Diabetes Mellitus 16
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Clinical Trial Locations for Metformin Hydrochloride; Repaglinide

Trials by Country

Trials by Country for Metformin Hydrochloride; Repaglinide
Location Trials
United States 36
China 12
Denmark 2
United Kingdom 2
Belgium 2
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Trials by US State

Trials by US State for Metformin Hydrochloride; Repaglinide
Location Trials
Texas 2
Georgia 2
New Jersey 1
Nevada 1
Nebraska 1
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Clinical Trial Progress for Metformin Hydrochloride; Repaglinide

Clinical Trial Phase

Clinical Trial Phase for Metformin Hydrochloride; Repaglinide
Clinical Trial Phase Trials
Phase 4 11
Phase 3 1
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for Metformin Hydrochloride; Repaglinide
Clinical Trial Phase Trials
Completed 16
Recruiting 2
Unknown status 1
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Clinical Trial Sponsors for Metformin Hydrochloride; Repaglinide

Sponsor Name

Sponsor Name for Metformin Hydrochloride; Repaglinide
Sponsor Trials
Novo Nordisk A/S 12
Steno Diabetes Center 2
University Hospital Birmingham 1
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Sponsor Type

Sponsor Type for Metformin Hydrochloride; Repaglinide
Sponsor Trials
Industry 14
Other 7
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Serving hundreds of leading biopharmaceutical companies globally:

Colorcon
Covington
Fuji
Daiichi Sankyo
Dow
US Department of Justice
Johnson and Johnson
Boehringer Ingelheim
Express Scripts

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