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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR MERREM

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Clinical Trials for Merrem

Trial ID Title Status Sponsor Phase Summary
NCT00050401 Ventilator-Associated Pneumonia/Hospital-Acquired Pneumonia Requiring Mechanical Ventilatory Support Completed AstraZeneca Phase 3 The purpose of the study is to find out if high dose antibiotic (meropenem, MERREM® I.V.), along with another drug called an aminoglycoside (a different type of antibiotic) is effective in decreasing or reducing the rate of antibiotic resistant Pseudomonas aeruginosa, Acinetobacter (germs that can cause pneumonia), and the rate of resistance in other difficult to treat germs which may cause hospital-acquired pneumonia requiring mechanical ventilatory support. The study hopes to show that by increasing the amount of meropenem administered and increasing the duration of infusion (release of the drug into the bloodstream), levels of the drug will stay at target levels in the bloodstream and decrease the ability of difficult to treat germs to resist, or not be killed by, the treatment using this antibiotic (meropenem) or other antibiotics.
NCT00061438 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed AstraZeneca Phase 4 This is a research study in patients having a condition known as necrotizing pancreatitis. This is inflammation of the pancreas (an intestinal organ which assists with digestion) that has resulted in the damage and death of some pancreatic tissue. This damaged pancreatic tissue may develop a bacterial infection, which can cause further -sometimes very serious- health problems. It may be possible to prevent or delay infection by giving 'prophylactic' antibiotics (that is - to provide protection before any infection starts). However, it is not certain that this antibiotic therapy will be successful. This study is being carried out to see whether the antibiotic 'Meropenem' (which is also known as MERREM I.V.) provides protection from developing a pancreatic infection. This will be done by comparing the progress of patients who receive meropenem with those who receive a non-active placebo solution (a solution that does not contain any active medication). Meropenem or placebo would be given in addition to the standard treatment received for pancreatitis. It is not known if meropenem will help prevent infections associated with necrotizing pancreatitis. Approximately 240 patients will take part in this study. Study participation will be carried out for up to 6 weeks, and patients will receive the study treatment up to a maximum of 21 days.
NCT00619710 Complicated Skin and Skin Structure Infections Completed AstraZeneca Phase 3 The purpose of this study is to demonstrate the non-inferiority of meropenem (Merrem) and imipenem in hospitalised subjects with complicated skin and skin structure infections.
NCT00891423 A Study of Meropenem Standard 30 Minute Infusion Versus Prolonged 3 Hour Infusion in Intensive Care Unit (ICU) Patients Completed Austin Health N/A Meropenem is a powerful antibiotic used in intensive care for people who have very serious infections. Meropenem is rapidly removed from the blood by the kidneys and it is very expensive. In very ill patients in intensive care, it is uncertain how best to give this antibiotic. Studies have suggested that a smaller dose given over a longer period of time, results in blood levels of meropenem that are just as good as when a higher dose is given over a shorter period of time. This direct comparison has not been tested in intensive care patients. It is important to know this because if giving a lesser amount more slowly is just as good, then doctors will choose to give meropenem this way. To establish whether this is the case, the investigators plan to conduct an initial (pilot) study in ten intensive care patients at Austin hospital. Adult (age 18 years or older) patients in intensive care who have a serious infection being treated with the antibiotic, meropenem for three days or more will be able to participate in this study. The decision to start meropenem will be made by the intensive care doctors and they will give it in the usual way for 24 hours. The investigators will then in a random way (like tossing of a coin), give the participant meropenem either in the usual way (1 gram infused over 30 minutes) or give them a smaller amount, but over a longer period of time (500 milligrams infused over 3 hours). This will be done for 24 hours. They will then receive meropenem in the alternative way for another 24 hours. After this time the intensive care doctors will decide how meropenem will continue to be given. Blood levels of meropenem will be measured to see if they are the same when meropenem is given in each of the two different ways. During each different way of giving meropenem, 7 blood samples will need to be taken. Ten mls (or one spoonful) of blood will be required for each measurement. Blood levels will be taken through monitoring lines, which will be already present. Other information will also be collected about the participant during this study. This will include their age, gender, height, weight, information about what other medical conditions they have and measurements of how well their kidneys are functioning.
NCT03174184 Phase 2a Study Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB Not yet recruiting Johns Hopkins University Phase 2 The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin resistance-conferring rpoB-gene mutations, the combination of meropenem and amoxicillin/clavulanate with rifampin has greater early bactericidal activity (EBA) than the combination of meropenem and amoxicillin/clavulanate without rifampin.
NCT03182504 A Study to Investigate the Intrapulmonary Lung Penetration of Nacubactam in Healthy Participants Not yet recruiting Hoffmann-La Roche Phase 1 The purpose of this study is to characterize the intrapulmonary penetration of nacubactam in healthy volunteers. Nacubactam is a novel non-beta-lactam beta-lactamase inhibitor being developed as a combination therapy with the beta-lactam meropenem for the treatment of serious gram-negative bacterial infections. Adult male and female healthy participants will receive a single intravenous infusion of nacubactam co-administered with meropenem and then undergo a bronchoalveolar lavage (BAL) procedure to collect lung epithelial lining fluid (ELF) for measurement of intrapulmonary concentrations of nacubactam and meropenem.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Merrem

Condition Name

Condition Name for Merrem
Intervention Trials
Pneumonia 1
Pancreatitis, Acute Necrotizing 1
Gram-negative Bacterial Infections 1
Cellulitis 1
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Condition MeSH

Condition MeSH for Merrem
Intervention Trials
Communicable Diseases 1
Gram-Negative Bacterial Infections 1
Cellulitis 1
Bacterial Infections 1
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Clinical Trial Locations for Merrem

Trials by Country

Trials by Country for Merrem
Location Trials
United States 16
Canada 2
South Africa 1
Australia 1
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Trials by US State

Trials by US State for Merrem
Location Trials
New York 2
Massachusetts 2
Washington 1
New Jersey 1
Maryland 1
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Clinical Trial Progress for Merrem

Clinical Trial Phase

Clinical Trial Phase for Merrem
Clinical Trial Phase Trials
Phase 4 1
Phase 3 2
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Merrem
Clinical Trial Phase Trials
Completed 4
Not yet recruiting 2
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Clinical Trial Sponsors for Merrem

Sponsor Name

Sponsor Name for Merrem
Sponsor Trials
AstraZeneca 3
Hoffmann-La Roche 1
Johns Hopkins University 1
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Sponsor Type

Sponsor Type for Merrem
Sponsor Trials
Industry 4
Other 2
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