Mono-menotropins Versus rFSH Protocol on Embryo Quality
Main Line Fertility Center
This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic
screening (PGS) of embryos to achieve pregnancy. The objective of this clinical trial is to
study the effect of mono-menotropins for COS versus recombinant follicle stimulating hormone
(rFSH) on cleavage-stage and blastocyst embryo quality after IVF. Embryo quality parameters
include conventional embryo grade, early embryo viability assessment (Eeva) time-lapse
parameters, and chromosomal aneuploidy rates after PGS.
This pilot study is expected to significantly contribute to optimization of treatment
regimens and stimulation protocols to optimize embryo quality.
MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population
Active, not recruiting
The purpose of this trial is to demonstrate non-inferiority of MENOPUR® versus recombinant
Follicle Stimulating Hormone (rFSH) (Gonal-f®) with respect to ongoing pregnancy rate in
women undergoing controlled ovarian stimulation (COS) following GnRH treatment.
Androgenic Profile Following Controlled Ovarian Stimulation
Not yet recruiting
Sheba Medical Center
In this study the investigators will try to discover whether there is a difference for any
of the stimulation preparations - recombinant FSH + recombinant LH (pergoveris & luveris)
vs. human menopausal gonadotropin (menopur) during GnRH-antagonist cycles in the meaning of
androgenic hormones profile. The study question is whether using recombinant LH will result
in different follicular hormonal milieu, serum endocrine profile or IVF outcomes than using
highly purified urinary gonadotropins with hCG mimicking LH activity.
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