The Safety and Effectiveness of Different Dose Levels of 1263W94 in the Treatment of Cytomegalovirus (CMV) of the Eyes in HIV-Infected Patients
To evaluate the safety and tolerability of multiple escalating doses of 1263W94 administered
orally for 28 days in HIV infected patients with asymptomatic CMV shedding. To obtain
preliminary evidence of the in vivo anti CMV activity of different doses of 1263W94 in humans
based on quantitative reduction of CMV load in semen and if possible in other biological
fluids and to explore the dose response relationship in the anti-CMV activity of 1263W94.
Maribavir for Prevention of CMV After Stem Cell Transplants
Cytomegalovirus (CMV) infections remain a significant problem following various types of
transplants that are associated with strong immunosuppressive therapy. Maribavir is a new
oral anti-CMV drug with a novel mechanism of action compared to currently available anti-CMV
drugs. This study will test the safety and anti-CMV activity of different doses of maribavir
when given as CMV prophylaxis following stem cell transplants.
Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients
The purpose of this research study is to investigate whether or not maribavir is safe and
effective for preventing CMV disease when taken by mouth for up to 12 weeks in patients who
have had a stem cell transplant.
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