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Last Updated: June 28, 2022

CLINICAL TRIALS PROFILE FOR MANGANESE CHLORIDE


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All Clinical Trials for Manganese Chloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03989310 ↗ An Open-label, Phase I/II Study of the Pan-immunotherapy in Patients With Local Advanced/Metastatic Pancreatic Cancer Recruiting Chinese PLA General Hospital Phase 1/Phase 2 2019-03-01 The outcome of pancreatic cancer is extremely poor. NCCN guidelines recommend FOLFIRINOX or modified-FOLFIRINOX as the first-line chemotherapeutic regimen, but the response rate is unacceptably low. PD-1 blockade has been developed to a new class of cancer immunotherapy that could restore an adequate immunosurveillance against the neoplasm and enhance T-cell-mediated anticancer immune responses. Manganese has been confirmed to activate antigen-presenting cells and function as mucosal immunoadjuvants in pre-clinical studies. This one-arm, phase I/II study is designed to assess the safety and efficacy of Manganese primed combined therapy of anti-PD-1 antibody and chemotherapy.
NCT03989336 ↗ An Open-label, Phase I/II Study of the Pan-immunotherapy in Patients With Relapsed/Refractory Ovarian Cancer Recruiting Chinese PLA General Hospital Phase 1/Phase 2 2019-06-20 Ovarian cancer is the most lethal gynecological cancer and the 5th leading cause of cancer death in women. Platinum chemotherapy has been widely adopted as a standard treatment for advanced ovarian cancer, the response rates in patients with relapsed/refractory ovarian cancer is unacceptably low. PD-1 blockade has been developed to a new class of cancer immunotherapy that could restore an adequate immunosurveillance against the neoplasm and enhance T-cell-mediated anticancer immune responses. Manganese has been confirmed to activate antigen-presenting cells and function as mucosal immunoadjuvants in pre-clinical studies. This two-arm, phase I/II study is designed to assess the safety and efficacy of combined therapy of anti-PD-1 antibody and chemotherapy with or without Manganese priming.
NCT03991559 ↗ A Safety Study of the Pan-immunotherapy in Patients With Unresectable/Metastatic Solid Tumors or Lymphomas Unknown status Chinese PLA General Hospital Phase 1 2018-11-01 Identification of T cell inhibitory signals, including PD-1/PD-L1, has prompted the development of a new class of cancer immunotherapy that could restore an adequate immunosurveillance against the neoplasm and enhance T-cell-mediated anticancer immune responses. However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which enable providing several therapeutic targets and tailoring of combinations of immune therapies. Manganese has been confirmed to activate antigen-presenting cells and function as mucosal immunoadjuvants in pre-clinical studies. This study is a first-in-man, Phase I, 3 + 3 dose escalation study of a combined regimen of Manganese and anti-PD-1 antibody with or without chemotherapies in subjects with unresectable/ metastatic solid tumors or lymphomas. This study is designed to assess the safety, tolerability, pharmacokinetic profile (PK profile), mode of delivery and Recommended Phase 2 Dose (RP2D) of this regimen.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Manganese Chloride

Condition Name

Condition Name for Manganese Chloride
Intervention Trials
Lymphoma 2
Solid Tumor 2
Ovarian Cancer 1
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Condition MeSH

Condition MeSH for Manganese Chloride
Intervention Trials
Lymphoma 2
Carcinoma, Ovarian Epithelial 1
Pancreatic Neoplasms 1
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Clinical Trial Locations for Manganese Chloride

Trials by Country

Trials by Country for Manganese Chloride
Location Trials
United States 10
China 5
Turkey 4
Sweden 1
Germany 1
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Trials by US State

Trials by US State for Manganese Chloride
Location Trials
Wisconsin 1
Washington 1
North Carolina 1
Missouri 1
Minnesota 1
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Clinical Trial Progress for Manganese Chloride

Clinical Trial Phase

Clinical Trial Phase for Manganese Chloride
Clinical Trial Phase Trials
Phase 3 1
Phase 1/Phase 2 4
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Manganese Chloride
Clinical Trial Phase Trials
Recruiting 4
Unknown status 2
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Clinical Trial Sponsors for Manganese Chloride

Sponsor Name

Sponsor Name for Manganese Chloride
Sponsor Trials
Chinese PLA General Hospital 5
Ascelia Pharma AB 1
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Sponsor Type

Sponsor Type for Manganese Chloride
Sponsor Trials
Other 5
Industry 1
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