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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Merck
Federal Trade Commission
Queensland Health
Chinese Patent Office
US Army
Covington
Chubb
Citi

Generated: July 16, 2018

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CLINICAL TRIALS PROFILE FOR METOPROLOL SUCCINATE

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Clinical Trials for METOPROLOL SUCCINATE

Trial ID Title Status Sponsor Phase Summary
NCT00077948 Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure Terminated AstraZeneca Phase 3 Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF). Some people with advanced CHF have difficulty taking beta-blocker medications due to troublesome side effects, such as low blood pressure and/or low heart rate, severe tiredness, dizziness, or shortness of breath. In other words, they have difficulty tolerating beta-blocker medications. The purpose of this study is to determine if enoximone can improve a patient's ability to tolerate a beta-blocker medication.
NCT00077948 Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure Terminated Gilead Sciences Phase 3 Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF). Some people with advanced CHF have difficulty taking beta-blocker medications due to troublesome side effects, such as low blood pressure and/or low heart rate, severe tiredness, dizziness, or shortness of breath. In other words, they have difficulty tolerating beta-blocker medications. The purpose of this study is to determine if enoximone can improve a patient's ability to tolerate a beta-blocker medication.
NCT00123903 COREG MR Versus TOPROL-XL On Reduction Of Microalbuminuria In Patients With Hypertension And Microalbuminuria Terminated GlaxoSmithKline Phase 3 This study was designed to determine whether COREG MR is more effective than TOPROL-XL in reducing microalbuminuria in type 2 diabetic or non-diabetic patients with high blood pressure and microalbuminuria.
NCT00255502 307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects Completed AstraZeneca Phase 3 This was a 52-week, multicenter, open-label study to determine the safety, tolerability and pharmacokinetics of TOPROL-XL (metoprolol succinate) extended-release tablets (metoprolol CR/XL) in hypertensive pediatric subjects. The study population included school age children (age 6 to 12 years < Tanner Stage 3) and adolescents (> 12 years old or > Tanner Stage 3 to 16 years old) of both genders. Because response to some therapies in adult hypertension appears to be different in black and non-black populations, the recruitment will have a mixture of black and non-black subjects. Pharmacokinetic measurements were performed on a subset of patients. Thirty subjects (15 subjects each in the 6 to 12 year age group and the 13 to 16 year age group) had a series of blood samples drawn. All subjects had a trough plasma level taken 24 hours after the last dose of open-label metoprolol CR/XL (Visit 18) with the exception of those subjects who completed Protocol 307B (16 week open-label treatment).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for METOPROLOL SUCCINATE

Condition Name

Condition Name for METOPROLOL SUCCINATE
Intervention Trials
Hypertension 15
Healthy 3
Fasting 2
Heart Failure 2
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Condition MeSH

Condition MeSH for METOPROLOL SUCCINATE
Intervention Trials
Hypertension 14
Heart Failure 6
Cardiomyopathies 2
Thalassemia 1
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Clinical Trial Locations for METOPROLOL SUCCINATE

Trials by Country

Trials by Country for METOPROLOL SUCCINATE
Location Trials
United States 105
China 27
Canada 12
India 5
Dominican Republic 2
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Trials by US State

Trials by US State for METOPROLOL SUCCINATE
Location Trials
New York 7
Pennsylvania 7
Utah 5
Colorado 5
Texas 5
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Clinical Trial Progress for METOPROLOL SUCCINATE

Clinical Trial Phase

Clinical Trial Phase for METOPROLOL SUCCINATE
Clinical Trial Phase Trials
Phase 4 11
Phase 3 11
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for METOPROLOL SUCCINATE
Clinical Trial Phase Trials
Completed 22
Recruiting 5
Terminated 5
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Clinical Trial Sponsors for METOPROLOL SUCCINATE

Sponsor Name

Sponsor Name for METOPROLOL SUCCINATE
Sponsor Trials
AstraZeneca 6
GlaxoSmithKline 4
Forest Laboratories 4
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Sponsor Type

Sponsor Type for METOPROLOL SUCCINATE
Sponsor Trials
Industry 31
Other 19
U.S. Fed 1
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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Queensland Health
Federal Trade Commission
Johnson and Johnson
Colorcon
McKesson
Deloitte
UBS
Medtronic

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