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AstraZeneca

Generated: July 21, 2018

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CLINICAL TRIALS PROFILE FOR METOPIRONE

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Clinical Trials for METOPIRONE

Trial ID Title Status Sponsor Phase Summary
NCT00567814 A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction Completed Embera NeuroTherapeutics, Inc. N/A Subjects will be randomly assigned to receive either one of the two potential dose combinations of the study medications or placebo over 6 weeks. The study will include twice weekly visits to the research clinic for laboratory studies, safety assessments and urine drug screens. Subjects will also be questioned regarding drug craving and mood symptoms.
NCT01673087 Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures Recruiting University of Michigan Phase 4 Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy to collect. However, the biological meaning of saliva cortisol measures has never been carefully examined. The goal of this study is to collect saliva from a large group of people as they go about their every-day lives, to measure their cortisol levels, and then study them in the laboratory where Investigators can learn more about how their stress response system (which produces cortisol) is really functioning. Investigators can then determine much more precisely what saliva cortisol levels really mean in terms of stress system biology. This will allow investigators to obtain much more useful information from the next decade of research on naturalistic stress and its biological impact using saliva cortisol measures, helping investigators to understand how stress undermines health and how to combat this effect.
NCT02297945 Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome Not yet recruiting HRA Pharma Phase 3 The purpose of this prospective, international phase III/IV study is to assess the efficacy and safety of metyrapone in patients with endogenous Cushing's syndrome during up to 36 weeks of treatment. The ability of metyrapone (250 mg capsules) to normalize urinary free cortisol (UFC) levels will be assessed during up to 36 weeks (9 months) of treatment.
NCT02856854 A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine Recruiting National Institute on Drug Abuse (NIDA) Phase 1 EMB-001 is a combination of 2 drugs: the cortisol synthesis inhibitor, metyrapone (Metopirone®), and the benzodiazepine receptor agonist, oxazepam (original trade name Serax®; now marketed as oxazepam (generic) only). This Phase 1b cocaine interaction study is being conducted in order to assess the safety and PK of EMB-001 and cocaine in combination.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for METOPIRONE

Condition Name

Condition Name for METOPIRONE
Intervention Trials
Cocaine Addiction 1
Stress 1
Cushing's Syndrome 1
Cocaine Use Disorder 1
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Condition MeSH

Condition MeSH for METOPIRONE
Intervention Trials
Behavior, Addictive 1
Syndrome 1
Cushing Syndrome 1
Cocaine-Related Disorders 1
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Clinical Trial Locations for METOPIRONE

Trials by Country

Trials by Country for METOPIRONE
Location Trials
United States 3
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Trials by US State

Trials by US State for METOPIRONE
Location Trials
Michigan 1
Louisiana 1
Kansas 1
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Clinical Trial Progress for METOPIRONE

Clinical Trial Phase

Clinical Trial Phase for METOPIRONE
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for METOPIRONE
Clinical Trial Phase Trials
Recruiting 2
Completed 1
Not yet recruiting 1
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Clinical Trial Sponsors for METOPIRONE

Sponsor Name

Sponsor Name for METOPIRONE
Sponsor Trials
Embera NeuroTherapeutics, Inc. 2
National Institute on Drug Abuse (NIDA) 1
HRA Pharma 1
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Sponsor Type

Sponsor Type for METOPIRONE
Sponsor Trials
Industry 3
NIH 1
Other 1
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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Accenture
Johnson and Johnson
Express Scripts
Baxter
Healthtrust
McKinsey
Merck
Fuji

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