Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
Completed
Montefiore Medical Center
Phase 4
2017-05-03
This is a randomized study, based in emergency departments, in which the investigators
determine the utility of adding various skeletal muscle relaxants to standard therapy, which
consists of ibuprofen and an educational session. Patients will be enrolled at the time of an
emergency visit and followed for three months to determine outcomes.
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
Completed
Rothman Institute Orthopaedics
N/A
2017-12-21
It is well recognized that a multimodal analgesia program targeting multiple pain pathways,
is more effective for controlling pain during the hospital stay and in the acute
postoperative period than monotherapy-based regimens, such as opioids only. This multimodal
analgesic regimen also leads to reduce opioid consumption and its related side effects after
hip and knee joint replacement procedures. One potential strategy to reduce the use of
opioids after TKA is to administer a prolonged oral multimodal pain regimen that targets
multiple pain pathways in the post hospital discharge period. This can be equal or more
effective than the regimen of opioid prescriptions used after TKA. To the best of our
knowledge, there have been no studies conducted that directly examine the effect of prolonged
multimodal pain regimen after hospital discharge in primary TKA patients.
PURPOSE:
1. To determine whether a prolonged multimodal pain regimen after discharge from primary
TKA can provide equivalent or better pain control while reducing opioid consumption and,
subsequently, opioid-related side effects.
2. To determine whether patient expectations and routine opioid prescription practices at
the time of discharge from primary TKA impacts opioid consumption.
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