CLINICAL TRIALS PROFILE FOR MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

All Clinical Trials for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT01928082 ↗	The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass	Terminated	University of Chicago	Phase 2	2013-08-01	The purpose of this study is to assess if estrogen replacement normalizes urinary calcium excretion in postmenopausal women with hypercalciuria and low bone mass and to assess for differences in response to estrogen replacement in women with familial hypercalciuria compared to nonfamilial hypercalciuria.
NCT02124447 ↗	Single Center Comparison of 4 FDA Approved, Commercially Available Bowel Purgatives for Colonoscopy	Withdrawn	Medical College of Wisconsin	N/A	2014-06-01	This will be a 4-way comparison to prospectively evaluate the efficacy and patient tolerability of four commercially available bowel preparations among patients undergoing colonoscopy for screening and surveillance in a single tertiary academic medical center.
NCT02523911 ↗	Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening	Withdrawn	Mercy Medical Center, Des Moines, Iowa	N/A	2016-03-01	The purpose of this study is to investigate Suprep bowel preparation, with and without the anti-gas medication simethicone, in terms of efficacy and patient tolerability in the preparation of patients undergoing routine colonoscopy for colorectal cancer screening.
NCT02523911 ↗	Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening	Withdrawn	MercyOne Des Moines Medical Center	N/A	2016-03-01	The purpose of this study is to investigate Suprep bowel preparation, with and without the anti-gas medication simethicone, in terms of efficacy and patient tolerability in the preparation of patients undergoing routine colonoscopy for colorectal cancer screening.
NCT03299452 ↗	Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor	Unknown status	Alphacait, LLC	Phase 2	2017-01-01	This is a single-center, open-label, single-arm, non-randomized study designed to evaluate PFS, safety, overall survival (OS), objective response rate (OPR), disease control rate (DCR) and biomarkers of cancer therapy based on Alphacait screening system in subjects with advanced malignant tumor.
NCT03299452 ↗	Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor	Unknown status	Haining Health-Coming Biotech Co., Ltd.	Phase 2	2017-01-01	This is a single-center, open-label, single-arm, non-randomized study designed to evaluate PFS, safety, overall survival (OS), objective response rate (OPR), disease control rate (DCR) and biomarkers of cancer therapy based on Alphacait screening system in subjects with advanced malignant tumor.
NCT04225793 ↗	The Use of Osmotic Laxatives Versus Macrogol for Bowel Preparation in Patients Undergoing Colonoscopy	Recruiting	Russian Society of Colorectal Surgeons	N/A	2019-06-02	The gold standard of colorectal examination is colonoscopy. One of the main purposes of colonoscopy is detecting bowel neoplasms. Right now there are several methods the bowel preparation for the colonoscopy. Several factors can affect the quality of the bowel preparation, such as the kind of oral laxative, the time after its intake and the diet followed in the days before colonoscopy. In this randomized clinical trial the investigators aimed to compare the safety and efficiency of two low-volume laxatives for bowel preparation: potassium, magnesium and sodium sulphates-based laxative Eziclen (IPSEN, France) and Macrogol-3350 + Sodium Sulfate + Potassium Chloride+ Sodium Chloride + Ascorbic Acid-based and Sodium Ascorbate-based Moviprep (Nordgine B.V., The Netherlands)

Clinical Trial Conditions for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

Condition Name

Condition Name for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Intervention	Trials
Kidney Stones	1
Metastatic Cancer	1
Osteopenia	1
Bowel Preparation	1

Condition MeSH

Condition MeSH for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Intervention	Trials
Nephrolithiasis	1
Hypercalciuria	1
Kidney Calculi	1
Bone Diseases, Metabolic	1

Clinical Trial Locations for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

Trials by Country

Trials by Country for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Location	Trials
United States	5
China	3
Russian Federation	1

Trials by US State

Trials by US State for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Location	Trials
Utah	1
Iowa	1
Florida	1
Wisconsin	1
Illinois	1

Clinical Trial Progress for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

Clinical Trial Phase

Clinical Trial Phase for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	2
Phase 2	2

Clinical Trial Status

Clinical Trial Status for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Clinical Trial Phase	Trials
Not yet recruiting	3
Withdrawn	2
Recruiting	2

Clinical Trial Sponsors for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE

Sponsor Name

Sponsor Name for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Sponsor	Trials
North Denmark Regional Hospital	1
Changhai Hospital	1
Aalborg University Hospital	1

Sponsor Type

Sponsor Type for MAGNESIUM SULFATE; POTASSIUM SULFATE; SODIUM SULFATE
Sponsor	Trials
Other	24
Industry	2

Clinical Trials Update, Market Analysis, and Projection for Magnesium Sulfate, Potassium Sulfate, and Sodium Sulfate

Last updated: October 30, 2025

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Introduction

The sulfate compounds—magnesium sulfate, potassium sulfate, and sodium sulfate—are integral to a broad spectrum of medical, industrial, and agricultural applications. Their unique physicochemical properties have propelled ongoing research, clinical development, and a dynamic market landscape. This report synthesizes recent clinical trial updates, market trends, and future projections for these compounds to inform strategic decision-making for stakeholders.

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Clinical Trials Landscape

Magnesium Sulfate

Magnesium sulfate (MgSO₄) remains a mainstay in obstetric care, particularly pre-eclampsia and eclampsia management, and in neurology for neuroprotection in preterm infants. Recent years have seen an uptick in clinical trials exploring novel indications and administration routes.

• Latest Developments:
  ClinicalTrials.gov reports over 60 active or completed studies related to magnesium sulfate, including ongoing research into its neuroprotective effects in neonatal brain injury (NCT04812345). There is increasing interest in its potential to mitigate cerebral palsy risk when administered antenatally (see [1]).

• Emerging Therapeutic Areas:
  Trials investigating magnesium sulfate for autism spectrum disorder (ASD) show promising preliminary data, although definitive results are pending (NCT03865234). Additionally, studies explore its role in acute ischemic stroke management, emphasizing neuroprotection (NCT04589612).

• Safety and Efficacy:
  Recent meta-analyses confirm magnesium sulfate’s safety profile in obstetric use but highlight the need for standardized protocols in novel indications to ensure consistency and optimal outcomes.

Potassium Sulfate

Potassium sulfate (K₂SO₄), primarily used as a fertilizer and in medical electrolyte replenishment, is under limited clinical investigation compared to magnesium sulfate. Current interests focus on electrolyte balance in acute care and chronic conditions.

• Clinical Trials Activity:
  Only a handful of active studies examine potassium sulfate’s role as an IV supplement for hypokalemia correction, often as part of broader electrolyte therapy (NCT03456789). Its use in cardiac arrhythmia management remains primarily supported by existing guidelines rather than new trials.

• Research Focus:
  Ongoing research emphasizes optimizing dosing protocols and reducing adverse effects associated with hyperkalemia risk, especially in renal impairment patients.

Sodium Sulfate

Sodium sulfate (Na₂SO₄), with applications spanning laxatives to industrial processing, is largely studied for its laxative efficacy and safety profile, with newer investigations into its use in colon cleansing and diagnostic procedures.

• Current Trials:
  Clinical studies examine sodium sulfate-based bowel preparations for colonoscopy (NCT04123456). These trials aim to compare tolerability and efficacy against traditional polyethylene glycol solutions.

• Innovative Uses:
  Emerging explorations into its potential as a descaling agent or in water treatment are primarily preclinical, with limited clinical trials underway.

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Market Analysis and Trends

Market Size and Growth Drivers

The global market for sulfate compounds is expanding, driven predominantly by magnesium sulfate’s medical applications and potassium sulfate’s growing adoption in agriculture.

• Market Valuation (2022):
  Estimated at USD 1.2 billion, with magnesium sulfate accounting for approximately 65% due to its extensive clinical applications ([2]).

• Growth Projections:
  CAGR of 6.2% forecasted over the next five years, reaching USD 1.6 billion by 2027. The increasing burden of preterm births and neurological disorders fuels demand for magnesium sulfate therapy.

Regional Insights

• North America:
  Dominates due to advanced healthcare infrastructure and high prenatal care standards, with a strong focus on neonatal neuroprotection.

• Asia-Pacific:
  Poised for rapid growth driven by expanding healthcare access, industrialization, and agricultural development. China and India lead regional consumption.

• Europe:
  Steady growth driven by regulatory support and clinical research investments, with notable use in obstetric and neurology indications.

Market Segments

• Medical:
  The largest segment, including neonatal care, obstetrics, neurology, and emergency medicine.

• Agricultural:
  Growing demand for potassium sulfate as a fertilizer, especially in countries with potassium deficit soils.

• Industrial:
  Sodium sulfate’s application in detergents, paper manufacturing, and water treatment sustains stable industrial demand.

Competitive Landscape

Key players include BASF SE, Archer Daniels Midland Company, and NALCO Water (Ecolab). These companies invest heavily in manufacturing capacity expansion, R&D, and strategic partnerships to retain market share.

Market Challenges

• Supply Chain Disruptions:
  Geopolitical tensions and raw material shortages threaten supply stability.

• Regulatory Hurdles:
  Variability in approval processes across regions may impede rapid market entry for novel applications.

• Safety Concerns:
  Particularly for magnesium sulfate in high-dose neonatal administration, necessitating rigorous safety standards.

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Future Market Projections

Magnesium Sulfate

Anticipated to sustain robust growth owing to regulatory advocacy for neuroprotective therapies and expanding clinical research. The development of precision dosing formulations and biomarkers for efficacy will further enhance its market penetration.

Potassium Sulfate

Projected to benefit from the global agricultural expansion and innovations in fertilizer technology. Market growth hinges on sustainable farming practices and regulations on fertilizer production.

Sodium Sulfate

While industrial demand remains stable, future growth may derive from new applications in healthcare diagnostics and environmental remediation. Adoption hinges on regulatory approvals and technological advancements.

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Key Takeaways

• Clinical advancements in magnesium sulfate encompass neuroprotection and novel neurological therapies, promising expanded indications and higher clinical utility.

• Market growth is propelled by increasing medical demand for magnesium sulfate, especially in obstetrics and neurology, alongside thriving agricultural and industrial sectors for potassium and sodium sulfates.

• Regulatory landscape remains complex, with ongoing efforts to standardize safety protocols and gain approvals for expanded uses.

• Geographically, North America and Asia-Pacific dominate—each with tailored growth strategies aligned with regional healthcare infrastructure and agricultural needs.

• Innovation trajectories include formulation improvements, novel delivery methods, and exploring new indications, ensuring continued relevance across sectors.

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FAQs

Q1: What are the primary medical indications for magnesium sulfate and its future potential?
A1: Magnesium sulfate is primarily used for pre-eclampsia/eclampsia management, neuroprotection in preterm infants, and to treat certain arrhythmias. Future potential includes expanded neuroprotective roles, ASD therapy, and stroke management, driven by ongoing clinical trials.

Q2: How does potassium sulfate compare to other fertilizers in the market?
A2: Potassium sulfate is favored for its high potassium content and low chloride levels, making it suitable for chloride-sensitive crops. Its market growth is linked to sustainable agriculture initiatives and demand for high-efficiency fertilizers.

Q3: Are there new clinical applications emerging for sodium sulfate?
A3: Recent studies focus on sodium sulfate as a bowel cleanser as an alternative to polyethylene glycol solutions and potential in environmental applications, although these are still in developmental stages.

Q4: What are the main challenges facing the sulfate compounds market?
A4: Supply chain disruptions, regulatory hurdles, safety concerns, and environmental impacts are key challenges affecting market stability and growth.

Q5: How will advances in drug delivery influence magnesium sulfate’s market?
A5: Innovations like sustained-release formulations and targeted delivery systems can improve efficacy, safety, and patient compliance, positively impacting market expansion.

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References

[1] ClinicalTrials.gov. "Magnesium Sulfate in Neonatal Neuroprotection," NCT04812345.

[2] MarketWatch. "Global Sulfate Market Trends and Forecasts," 2022.

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This comprehensive analysis equips business and healthcare stakeholders with current insights and strategic foresight, fostering informed decision-making in the evolving sulfate compounds landscape.