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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR LOXAPINE HYDROCHLORIDE

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Clinical Trials for Loxapine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00122733 Loxapine and Weaning From Ventilator Completed Assistance Publique - Hôpitaux de Paris N/A Patients may be very agitated during the weaning period from mechanical ventilation. Administration of loxapine, a neuroleptic that does not notably affect ventilatory drive, may help in obtaining an adequate level of cooperation and, therefore, in reducing the duration of mechanical ventilation.
NCT00290082 Randomized Double-blind Trial of Midazolam and Loxapine in Agitated Patients Terminated University Hospital, Rouen Phase 3 Neuroleptics are used since a long time in the management of severely agitated patients. Loxapine is routinely used in our country, with, to our knowledge no severe adverse event reported, in this indication. However, recently, benzodiazepines have appeared interesting in agitated patients, with the use of midazolam. The aim of this study is to compare midazolam to loxapine in the treatment of severe agitated patients admitted in the emergency department.
NCT00369577 StaccatoTM Loxapine for Inhalation in Schizophrenic Patients With Agitation. Completed Alexza Pharmaceuticals, Inc. Phase 2 The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients. The study will be conducted in 120 agitated schizophrenic patients - either newly admitted to a hospital setting or a research unit for acute agitation or already in hospital for chronic underlying conditions. Patients meeting entry criteria will be randomized to one of two doses of Staccato Loxapine or to Staccato Placebo. Following administration of study drug, assessment of agitation state will be conducted at serial time points using standard agitation scales over a 24 hour period.
NCT00444028 Staccato® Loxapine for Inhalation in Schizophrenia Completed Alexza Pharmaceuticals, Inc. Phase 1 Staccato Loxapine is being developed for the treatment of acute agitation in patients with schizophrenia. A 50 patient, dose escalation Phase I clinical trial was completed in November 2005.
NCT00489476 Staccato® Loxapine for Inhalation in Patients With Migraine Headache Completed Alexza Pharmaceuticals, Inc. Phase 2 The objective of this trial is to assess the efficacy and safety of Staccato Loxapine in patients with migraine headache with or without aura in a clinical setting.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Loxapine Hydrochloride

Condition Name

Condition Name for Loxapine Hydrochloride
Intervention Trials
Schizophrenia 4
Healthy 3
Bipolar Disorder 2
Chronic Obstructive Pulmonary Disease 1
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Condition MeSH

Condition MeSH for Loxapine Hydrochloride
Intervention Trials
Psychomotor Agitation 8
Schizophrenia 4
Disease 3
Bipolar Disorder 2
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Clinical Trial Locations for Loxapine Hydrochloride

Trials by Country

Trials by Country for Loxapine Hydrochloride
Location Trials
United States 44
France 4
Canada 2
Germany 1
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Trials by US State

Trials by US State for Loxapine Hydrochloride
Location Trials
Georgia 5
California 4
Indiana 4
Ohio 3
Massachusetts 2
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Clinical Trial Progress for Loxapine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Loxapine Hydrochloride
Clinical Trial Phase Trials
Phase 4 3
Phase 3 3
Phase 2 5
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Clinical Trial Status

Clinical Trial Status for Loxapine Hydrochloride
Clinical Trial Phase Trials
Completed 17
Recruiting 3
Terminated 2
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Clinical Trial Sponsors for Loxapine Hydrochloride

Sponsor Name

Sponsor Name for Loxapine Hydrochloride
Sponsor Trials
Alexza Pharmaceuticals, Inc. 12
Assistance Publique - Hôpitaux de Paris 2
University of Arkansas 1
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Sponsor Type

Sponsor Type for Loxapine Hydrochloride
Sponsor Trials
Industry 15
Other 13
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