Pediatric Kidney Transplant Without Calcineurin Inhibitors
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to see the effect of using drugs other than calcineurin
inhibitors to improve the rate of kidney transplant failure.
Kidney transplantation can help children with end-stage kidney disease. However, it has been
difficult to find treatment for donor graft rejection that does not have a lot of side
effects. Researchers hope to find treatments (immunosuppressants) with fewer side effects.
One approach is to avoid using calcineurin inhibitors and to try a new drug known as
sirolimus instead. Another is to use steroids less often. This study will test whether using
sirolimus, fewer steroid treatments, MMF, and certain antibodies will improve long-term
graft survival in children receiving kidney transplants from living donors.
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