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Pediatric Kidney Transplant Without Calcineurin Inhibitors
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
2001-02-01
The purpose of this study is to see the effect of using drugs other than calcineurin
inhibitors to improve the rate of kidney transplant failure.
Kidney transplantation can help children with end-stage kidney disease. However, it has been
difficult to find treatment for donor graft rejection that does not have a lot of side
effects. Researchers hope to find treatments (immunosuppressants) with fewer side effects.
One approach is to avoid using calcineurin inhibitors and to try a new drug known as
sirolimus instead. Another is to use steroids less often. This study will test whether using
sirolimus, fewer steroid treatments, MMF, and certain antibodies will improve long-term
graft survival in children receiving kidney transplants from living donors.
Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)
Completed
Laura Schanberg
Phase 3
2003-09-01
The purpose of this study is:
1. To assess the efficacy of a lipid-lowering agent (atorvastatin) on the development of
atherosclerosis that predisposes children with SLE to cardiovascular events in
adulthood.
2. To assess the safety of intermediate-term (36 months) treatment of children and young
adults with atorvastatin.
3. To further characterize the course of SLE in children and young adults, by establishing
a cohort of pediatric SLE patients to be followed prospectively.
4. To establish a mechanism for conducting clinical trials in rare pediatric rheumatic
diseases using the Children's Arthritis and Rheumatology Research Alliance (CARRA).
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