CLINICAL TRIALS PROFILE FOR LEVONORGESTREL AND ETHINYL ESTRADIOL

All Clinical Trials for Levonorgestrel And Ethinyl Estradiol

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00117273 ↗	A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens	Completed	Duramed Research	Phase 3	2005-06-01	This is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy, reproductive-aged women using three different regimens of oral contraceptives (OCs). Two extended regimen OCs, Seasonale (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of placebo), and Seasonique (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of ethinyl estradiol 0.01 mg), and a 28-day regimen OC, Portia (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 21 days followed by 7 days of placebo).
NCT00128934 ↗	Study Evaluating Combination of Levonorgestrel (LNG) and Ethinyl Estradiol (EE) in Premenstrual Dysphoric Disorder	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	Phase 3	2005-08-01	The purpose of this study is to determine whether levonorgestrel (LNG)/ethinyl estradiol (EE) is effective in treating the symptoms of severe premenstrual syndrome (PMS).
NCT00161681 ↗	Study Evaluating Levonorgestrel/Ethinyl Estradiol (LNG/EE) in PMS	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	Phase 3	2005-07-01	The purpose of this study is to determine whether LNG/EE is effective in the treatment of menstrual cycle related symptoms.
NCT00195559 ↗	Study Evaluating Combination of Levonorgestrel and Ethinyl Estradiol in Pre-Menstrual Dysphoric Disorder	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	Phase 3	2005-09-01	The purpose of this study is to determine whether Levonorgestrel/Ethinyl Estradiol (LNG/EE) is effective in treating the symptoms of severe Premenstrual Dysphoric Disorder.
NCT00204451 ↗	Human Ovarian Follicular Dynamics and Emergency Contraception	Completed	Canadian Institutes of Health Research (CIHR)	Phase 4	2005-07-01	The researchers hypothesize that emergency contraception (EC) will initiate the changes associated with atresia or ovulatory failure at all stages of follicular development and that the image attributes associated with atresia will be similar regardless of the diameter of the dominant follicle when ovarian suppression is initiated. Second, changes associated with atresia may be observed, but ovulation of the dominant follicle is unimpeded.
NCT00204451 ↗	Human Ovarian Follicular Dynamics and Emergency Contraception	Completed	University of Saskatchewan	Phase 4	2005-07-01	The researchers hypothesize that emergency contraception (EC) will initiate the changes associated with atresia or ovulatory failure at all stages of follicular development and that the image attributes associated with atresia will be similar regardless of the diameter of the dominant follicle when ovarian suppression is initiated. Second, changes associated with atresia may be observed, but ovulation of the dominant follicle is unimpeded.
NCT00213096 ↗	Effects of Hormonal Contraceptives on Liver Proteins and Coagulation Factors: A Comparison of a Contraceptive Vaginal Ring and an Oral Contraceptive	Completed	United States Agency for International Development (USAID)	Phase 2	2003-03-01	The purpose of this 3-month (cycle) study was to evaluate the effects of hormonal contraceptives containing a progestin and an estrogen on liver proteins and coagulation factors that are sensitive to estrogen. In this study, a contraceptive vaginal ring containing Nestorone® (a progestin with no androgenic properties) and ethinyl estradiol was compared to an oral contraceptive containing levonorgestrel (an androgenic progestin) and ethinyl estradiol.

Clinical Trial Conditions for Levonorgestrel And Ethinyl Estradiol

Condition Name

Condition Name for Levonorgestrel And Ethinyl Estradiol
Intervention	Trials
Contraception	14
Healthy	11
Bioequivalence	3
Drug Interactions	3

Condition MeSH

Condition MeSH for Levonorgestrel And Ethinyl Estradiol
Intervention	Trials
Premenstrual Syndrome	3
Endometriosis	3
Sclerosis	2
Multiple Sclerosis	2

Clinical Trial Locations for Levonorgestrel And Ethinyl Estradiol

Trials by Country

Trials by Country for Levonorgestrel And Ethinyl Estradiol
Location	Trials
United States	127
Germany	12
China	12
Mexico	6
Canada	6

Trials by US State

Trials by US State for Levonorgestrel And Ethinyl Estradiol
Location	Trials
Florida	12
California	8
Arizona	7
Texas	7
Ohio	6

Clinical Trial Progress for Levonorgestrel And Ethinyl Estradiol

Clinical Trial Phase

Clinical Trial Phase for Levonorgestrel And Ethinyl Estradiol
Clinical Trial Phase	Trials
Phase 4	7
Phase 3	16
Phase 2/Phase 3	1

Clinical Trial Status

Clinical Trial Status for Levonorgestrel And Ethinyl Estradiol
Clinical Trial Phase	Trials
Completed	41
Recruiting	5
Withdrawn	3

Clinical Trial Sponsors for Levonorgestrel And Ethinyl Estradiol

Sponsor Name

Sponsor Name for Levonorgestrel And Ethinyl Estradiol
Sponsor	Trials
Wyeth is now a wholly owned subsidiary of Pfizer	8
Bayer	5
Agile Therapeutics	5

Sponsor Type

Sponsor Type for Levonorgestrel And Ethinyl Estradiol
Sponsor	Trials
Industry	53
Other	17
U.S. Fed	1