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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR LETROZOLE

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Clinical Trials for Letrozole

Trial ID Title Status Sponsor Phase Summary
NCT00001521 Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia Active, not recruiting Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1 This study was developed to determine if a combination of four drugs (flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone) can normalize growth in children with congenital adrenal hyperplasia. The study will take 60 children, boys and girls and divide them into 2 groups based on the medications given. Group one will receive the new four- drug combination. Group two will receive the standard treatment for congenital adrenal hyperplasia (hydrocortisone and fludrocortisone). The boys in group one will take the medication until the age of 14 at which time they will stop taking the four drug combination and begin receiving the standard treatment for congenital adrenal hyperplasia. Girls in group one will take the four drug combination until the age of 13, at which time they will stop and begin receiving the standard treatment for congenital adrenal hyperplasia plus flutamide. Flutamide will be given to the girls until six months after their first menstrual period. All of the children will be followed until they reach their final adult height. The effectiveness of the treatment will be determined by measuring the patient's adult height, body mass index, and bone density.
NCT00003140 Letrozole After Tamoxifen in Treating Women With Breast Cancer Completed Cancer and Leukemia Group B Phase 3 RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by reducing the production of estrogen. PURPOSE: This randomized phase III trial is studying letrozole to see how well it works in treating women with breast cancer who have received tamoxifen for at least 5 years.
NCT00003140 Letrozole After Tamoxifen in Treating Women With Breast Cancer Completed Eastern Cooperative Oncology Group Phase 3 RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by reducing the production of estrogen. PURPOSE: This randomized phase III trial is studying letrozole to see how well it works in treating women with breast cancer who have received tamoxifen for at least 5 years.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Letrozole

Condition Name

Condition Name for Letrozole
Intervention Trials
Breast Cancer 149
Infertility 25
Breast Neoplasms 22
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Condition MeSH

Condition MeSH for Letrozole
Intervention Trials
Breast Neoplasms 244
Infertility 33
Polycystic Ovary Syndrome 26
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Clinical Trial Locations for Letrozole

Trials by Country

Trials by Country for Letrozole
Location Trials
Italy 159
Canada 104
Spain 90
United Kingdom 88
Japan 86
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Trials by US State

Trials by US State for Letrozole
Location Trials
California 62
Texas 59
Massachusetts 44
Florida 44
New York 38
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Clinical Trial Progress for Letrozole

Clinical Trial Phase

Clinical Trial Phase for Letrozole
Clinical Trial Phase Trials
Phase 4 28
Phase 3 80
Phase 2/Phase 3 14
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Clinical Trial Status

Clinical Trial Status for Letrozole
Clinical Trial Phase Trials
Completed 117
Recruiting 105
Active, not recruiting 55
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Clinical Trial Sponsors for Letrozole

Sponsor Name

Sponsor Name for Letrozole
Sponsor Trials
Novartis Pharmaceuticals 53
National Cancer Institute (NCI) 46
Novartis 27
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Sponsor Type

Sponsor Type for Letrozole
Sponsor Trials
Other 372
Industry 189
NIH 53
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