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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR LITHANE


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All Clinical Trials for LITHANE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00400088 ↗ Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide Terminated Nova Scotia Health Authority Phase 3 2007-06-01 This study is being done to look at how well people respond to two very different drug treatments for depression. Clinically, people with depression can respond differently to drug treatments for reasons which are not always clear. Some of our own recent research suggests that people with depression who have a family history of bipolar disorder or completed suicide, may react differently to standard antidepressant medications than those without such a family history. Our data shows that family history of completed suicide, as well as the known predictor of family history of bipolar disorder, may help identify a pre-bipolar high risk group i.e. they currently have depression but at some future date will declare a bipolar illness (manic-depression) by virtue of development of a manic episode also. Our research suggests that treatment- emergent symptoms in response to a trial of antidepressant, such as agitation may be strong predictors of future bipolarity and inherently dangerous particularly as they are not ascribed to the antidepressant treatment. Finally, it is possible that this subgroup of those with depressive illness may respond better and more safely to lithium, a mood stabiliser used in known bipolar depression. The objective of this proposal is to investigate response to acute lithium treatment in subjects who meet the diagnostic criteria for major depression, but who are potentially at risk for bipolar disorder, by virtue of family history of bipolarity or completed suicide.
NCT00408681 ↗ Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant Completed National Cancer Institute (NCI) N/A 2006-06-01 RATIONALE: Lithium carbonate may be an effective treatment for intestinal graft-versus-host disease caused by a donor stem cell transplant. PURPOSE: This clinical trial is studying lithium carbonate in treating patients with acute intestinal graft-versus-host-disease after donor stem cell transplant.
NCT00408681 ↗ Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant Completed Fred Hutchinson Cancer Research Center N/A 2006-06-01 RATIONALE: Lithium carbonate may be an effective treatment for intestinal graft-versus-host disease caused by a donor stem cell transplant. PURPOSE: This clinical trial is studying lithium carbonate in treating patients with acute intestinal graft-versus-host-disease after donor stem cell transplant.
NCT00870311 ↗ Investigation of Lithium on Signal Transduction, Gene Expression and Brain Myo-Inositol Levels in Manic Patients Completed National Institute of Mental Health (NIMH) Phase 4 1996-03-01 This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hypothesized that specific changes in these markers will correlate with lithium treatment responsiveness.
NCT00870311 ↗ Investigation of Lithium on Signal Transduction, Gene Expression and Brain Myo-Inositol Levels in Manic Patients Completed Wayne State University Phase 4 1996-03-01 This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hypothesized that specific changes in these markers will correlate with lithium treatment responsiveness.
NCT03290963 ↗ Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine Withdrawn William V. Bobo, M.D. Phase 2 2017-11-30 The purpose of this research study is to compare the antidepressant effect of lithium versus placebo in adults receiving ketamine. Lithium is available commercially for depression; ketamine is available commercially and can help the symptoms of depression; however, it has not been approved by the U.S. Food and Drug Administration (FDA) for this use. The FDA has allowed the use of this drug in this research study.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for LITHANE

Condition Name

Condition Name for LITHANE
Intervention Trials
Recurrent Childhood Acute Myeloid Leukemia 1
Stage III Adult Diffuse Small Cleaved Cell Lymphoma 1
Disseminated Neuroblastoma 1
Stage IV Small Lymphocytic Lymphoma 1
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Condition MeSH

Condition MeSH for LITHANE
Intervention Trials
Depression 2
Bipolar Disorder 2
Depressive Disorder 2
Leukemia, Neutrophilic, Chronic 1
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Clinical Trial Locations for LITHANE

Trials by Country

Trials by Country for LITHANE
Location Trials
United States 3
Canada 1
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Trials by US State

Trials by US State for LITHANE
Location Trials
Minnesota 1
Michigan 1
Washington 1
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Clinical Trial Progress for LITHANE

Clinical Trial Phase

Clinical Trial Phase for LITHANE
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for LITHANE
Clinical Trial Phase Trials
Completed 2
Terminated 1
Withdrawn 1
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Clinical Trial Sponsors for LITHANE

Sponsor Name

Sponsor Name for LITHANE
Sponsor Trials
Nova Scotia Health Authority 1
National Cancer Institute (NCI) 1
Fred Hutchinson Cancer Research Center 1
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Sponsor Type

Sponsor Type for LITHANE
Sponsor Trials
Other 4
NIH 2
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