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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR LEVOFLOXACIN


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All Clinical Trials for LEVOFLOXACIN

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000778 ↗ A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 1969-12-31 To evaluate the methodology for rapidly determining the early bactericidal activity (EBA), tolerance, and pharmacokinetics of isoniazid and levofloxacin in the treatment of pulmonary tuberculosis (TB). Traditionally, in trials for treatment of TB, a new drug is administered in combination with two or more other antituberculous agents of known effectiveness over a long period of time. In this setting, it is difficult to determine the effect of any single drug or dose level. Development of new agents for the treatment of TB may be accelerated by a methodology in which a new agent could be evaluated for activity by administering it as a single agent over a short time period. This study utilizes a method to measure the amount of bacteria present each day in the lungs.
NCT00000796 ↗ A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDR Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To determine the demographic, behavioral, clinical, and geographic risk factors associated with the occurrence of multidrug-resistant pulmonary tuberculosis (MDRTB). To evaluate the clinical and microbiological responses and overall survival of MDRTB patients who are treated with levofloxacin-containing multiple-drug regimens chosen from a hierarchical list. Per 9/28/94 amendment, to assess whether persistent or recurrent positive sputum cultures of patients who show failure or relapse are due to the same strain or reinfection with a new strain. Among TB patients, there has been an increase in progressive disease due to the emergence of antimycobacterial drug-resistant strains of Mycobacterium tuberculosis. Failure to identify patients at high risk for MDRTB increases the hazard for both treatment failure and development of resistance to additional therapeutic agents. Efforts to improve survival in patients with MDRTB will depend on improved methods of assessing the risk of acquisition of MDRTB and identifying drug susceptibility patterns in a timely fashion.
NCT00001033 ↗ The Treatment of Tuberculosis in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 1969-12-31 PER 5/30/95 AMENDMENT: To compare the combined rate of failure during therapy and relapse after therapy between two durations of intermittent therapy (6 versus 9 months) for the treatment of pulmonary tuberculosis (TB) in HIV-infected patients. To compare toxicity, survival, and development of resistance in these two regimens. ORIGINAL: To compare the efficacy and safety of induction and continuation therapies for the treatment of pulmonary TB in HIV-infected patients who are either from areas with known high rates of resistance to one or more anti-TB drugs or from areas where TB is expected to be susceptible to commonly used anti-TB drugs. PER 5/30/95 AMENDMENT: In HIV-negative patients, intermittent anti-TB therapy has been shown to be as effective as daily therapy, but the optimal duration of therapy in HIV-infected patients has not been established. ORIGINAL: In some areas of the country, resistance to one or more of the drugs commonly used to treat TB has emerged. Thus, the need to test regimens containing a new drug exists. Furthermore, the optimal duration of anti-TB therapy for HIV-infected patients with TB needs to be determined.
NCT00002249 ↗ A Double-Blind Study to Evaluate the Safety and Pharmacokinetics of L-Ofloxacin (RWJ 25213) in Subjects With HIV Infection Completed R W Johnson Pharmaceutical Research Institute Phase 1 1969-12-31 To determine the safety and pharmacokinetics of L-ofloxacin (RWJ 25213) in patients with HIV infection.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for LEVOFLOXACIN

Condition Name

Condition Name for LEVOFLOXACIN
Intervention Trials
Helicobacter Pylori Infection 39
Cataract 8
Tuberculosis 8
Pneumonia 8
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Condition MeSH

Condition MeSH for LEVOFLOXACIN
Intervention Trials
Infections 59
Infection 52
Communicable Diseases 43
Helicobacter Infections 37
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Clinical Trial Locations for LEVOFLOXACIN

Trials by Country

Trials by Country for LEVOFLOXACIN
Location Trials
United States 521
China 84
Italy 56
Canada 40
South Africa 31
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Trials by US State

Trials by US State for LEVOFLOXACIN
Location Trials
Florida 29
California 29
Michigan 24
Texas 23
Pennsylvania 22
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Clinical Trial Progress for LEVOFLOXACIN

Clinical Trial Phase

Clinical Trial Phase for LEVOFLOXACIN
Clinical Trial Phase Trials
Phase 4 86
Phase 3 80
Phase 2/Phase 3 10
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Clinical Trial Status

Clinical Trial Status for LEVOFLOXACIN
Clinical Trial Phase Trials
Completed 154
Unknown status 38
Recruiting 36
[disabled in preview] 18
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Clinical Trial Sponsors for LEVOFLOXACIN

Sponsor Name

Sponsor Name for LEVOFLOXACIN
Sponsor Trials
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 25
PriCara, Unit of Ortho-McNeil, Inc. 21
National Taiwan University Hospital 12
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Sponsor Type

Sponsor Type for LEVOFLOXACIN
Sponsor Trials
Other 397
Industry 150
NIH 15
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