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Last Updated: March 29, 2024

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CLINICAL TRIALS PROFILE FOR LENVIMA


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All Clinical Trials for LENVIMA

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02430714 ↗ Post-marketing Surveillance of Lenvatinib Mesylate (Lenvima Capsule) in Patients With Unresectable Thyroid Cancer (Study LEN01T) Completed Eisai Co., Ltd. 2015-05-20 This study is a post-marketing surveillance of lenvatinib in participants with unresectable thyroid cancer. The objectives of this study are to capture unknown adverse reactions, incidences of adverse drug reaction, efficacy, factors considered to have effect to safety and effectiveness, and incidences of hypertension, hemorrhagic events and thromboembolic event, and liver disorder.
NCT02501096 ↗ Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors Active, not recruiting Merck Sharp & Dohme Corp. Phase 1/Phase 2 2015-07-22 This is an open-label Phase 1b/2 trial of lenvatinib (E7080) plus pembrolizumab in participants with selected solid tumors. Phase 1b will determine and confirm the maximum tolerated dose (MTD) for lenvatinib in combination with 200 milligrams (mg) (intravenous [IV], every 3 weeks [Q3W]) pembrolizumab in participants with selected solid tumors (i.e. non-small cell lung cancer, renal cell carcinoma, endometrial carcinoma, urothelial carcinoma, squamous cell carcinoma of the head and neck, or melanoma). Phase 2 (Expansion) will evaluate the safety and efficacy of the combination in 6 cohorts at the MTD from Phase 1b (lenvatinib 20 mg/day orally + pembrolizumab 200 mg Q3W, IV).
NCT02501096 ↗ Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors Active, not recruiting Eisai Inc. Phase 1/Phase 2 2015-07-22 This is an open-label Phase 1b/2 trial of lenvatinib (E7080) plus pembrolizumab in participants with selected solid tumors. Phase 1b will determine and confirm the maximum tolerated dose (MTD) for lenvatinib in combination with 200 milligrams (mg) (intravenous [IV], every 3 weeks [Q3W]) pembrolizumab in participants with selected solid tumors (i.e. non-small cell lung cancer, renal cell carcinoma, endometrial carcinoma, urothelial carcinoma, squamous cell carcinoma of the head and neck, or melanoma). Phase 2 (Expansion) will evaluate the safety and efficacy of the combination in 6 cohorts at the MTD from Phase 1b (lenvatinib 20 mg/day orally + pembrolizumab 200 mg Q3W, IV).
NCT02579616 ↗ Study of Lenvatinib (E7080) in Unresectable Biliary Tract Cancer (BTC) Who Failed Gemcitabine-based Combination Chemotherapy Completed Eisai Co., Ltd. Phase 2 2015-10-23 This is a multicenter, single arm, open-label study in participants with unresectable BTC and disease progression or failure following one prior gemcitabine-based doublet chemotherapy regimen (combination of gemcitabine and cisplatin, or gemcitabine and other platinum agent/fluoropyrimidine agent). This study contains 3 phases: a Pre-treatment phase that will last within 21 days; a Treatment phase that will consist of study treatment cycles and tumor assessment conducted every 6-8 weeks; and a Follow-up phase that will begin immediately after the Off-Treatment Visit and will continue as long as the participant is alive, unless the participant withdraws consent, or until the End of Study.
NCT02592356 ↗ Effect of Cabozantinib S-Malate or Lenvatinib Mesylate on Weight and Body Composition in Patients With Metastatic Endocrine Cancer Active, not recruiting National Cancer Institute (NCI) N/A 2015-11-16 The goal of this clinical research study is to learn about possible weight, muscle, and/or fat loss in patients receiving cabozantinib or lenvatinib.
NCT02592356 ↗ Effect of Cabozantinib S-Malate or Lenvatinib Mesylate on Weight and Body Composition in Patients With Metastatic Endocrine Cancer Active, not recruiting M.D. Anderson Cancer Center N/A 2015-11-16 The goal of this clinical research study is to learn about possible weight, muscle, and/or fat loss in patients receiving cabozantinib or lenvatinib.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for LENVIMA

Condition Name

Condition Name for LENVIMA
Intervention Trials
Hepatocellular Carcinoma 6
Advanced Cancer 3
Liver Transplant; Complications 3
Renal Cell Carcinoma 3
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Condition MeSH

Condition MeSH for LENVIMA
Intervention Trials
Carcinoma 25
Carcinoma, Hepatocellular 11
Neoplasms 9
Thyroid Neoplasms 7
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Clinical Trial Locations for LENVIMA

Trials by Country

Trials by Country for LENVIMA
Location Trials
United States 91
France 19
Japan 16
Spain 15
Australia 14
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Trials by US State

Trials by US State for LENVIMA
Location Trials
California 10
Massachusetts 9
Texas 9
New York 7
Florida 5
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Clinical Trial Progress for LENVIMA

Clinical Trial Phase

Clinical Trial Phase for LENVIMA
Clinical Trial Phase Trials
Phase 3 3
Phase 2 32
Phase 1/Phase 2 5
[disabled in preview] 11
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Clinical Trial Status

Clinical Trial Status for LENVIMA
Clinical Trial Phase Trials
Not yet recruiting 20
Recruiting 18
Active, not recruiting 5
[disabled in preview] 8
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Clinical Trial Sponsors for LENVIMA

Sponsor Name

Sponsor Name for LENVIMA
Sponsor Trials
Merck Sharp & Dohme Corp. 16
Eisai Inc. 12
Eisai Co., Ltd. 4
[disabled in preview] 10
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Sponsor Type

Sponsor Type for LENVIMA
Sponsor Trials
Other 53
Industry 50
NIH 4
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