The purpose of this study is to try different medications in patients with low blood pressure
and other problems with their involuntary (autonomic) nervous system. The pharmacological
trials in this study will perhaps lead to more effective treatment. This study consists of
single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months)
trials.
The purpose of this study is to try different medications in patients with low blood pressure
and other problems with their involuntary (autonomic) nervous system. The pharmacological
trials in this study will perhaps lead to more effective treatment. This study consists of
single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months)
trials.
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
Completed
University of Arkansas
Phase 4
2016-03-01
The purpose of this study is to investigate a new use for a medication called levodopa
(L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic
Stress Disorder (PTSD). L-DOPA is thought to enhance certain cognitive abilities that the
investigators believe may be affected among women with PTSD. It is hypothesized that L-DOPA
may enhance fear extinction learning to a conditioned fear stimulus. If this is true, L-DOPA
may improve outcomes for those undergoing certain types of therapy for PTSD, though that aim
is beyond the scope of this project. Additionally, the investigators are testing whether an
individual's genetic profile affects how well L-DOPA works to enhance cognitive abilities.
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