CLINICAL TRIALS PROFILE FOR KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
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All Clinical Trials for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT06457100 ↗ | Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery | ACTIVE_NOT_RECRUITING | The Second People's Hospital of Huai'an | PHASE1 | 2023-11-21 | Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of chronic sinusitis, with the advantages of deep approach, light trauma, and less pain. However, because the operation area involves the nose, eyes and cranial region, the surrounding tissue structure is complex and rich in blood vessels and nerves, and the use of epinephrine, intraoperative tissue damage, nerve stimulation, and postoperative inflammation, edema, hemorrhage, and nasal cavity stuffing can cause patients' stress reaction and postoperative pain, resulting in patients' anxiety, depression, and sleep disorders, which can reduce the quality of early postoperative recovery, and affect the patients' rapid postoperative recovery. Esmolol is a selective β1-adrenergic receptor blocker with fast onset of action and short duration of action, which has the ability to reduce heart rate, blood pressure and myocardial protection. In recent years, several studies have found that esmolol not only reduces perianesthesia stress, but also reduces postoperative pain, decreases intraoperative and postoperative opioid requirements, and reduces the incidence of postoperative nausea and vomiting.In addition, intravenous lidocaine infusion has been shown to improve the quality of early postoperative recovery and accelerate postoperative recovery in patients with FESS.However, the dose of the drug administered is unclear and the range of safe infusion doses is narrow, requiring plasma concentration monitoring to prevent toxic reactions to local anesthetics. Its clinical application may lead to prolonged sinus bradycardia, increasing the cardiovascular risk of patients. Therefore, this study was designed to characterize the FESS procedure with the aim of determining that esmolol is not inferior to lidocaine in FESS in terms of the quality of postoperative recovery and is more advantageous in terms of controlling hemorrhage, guaranteeing a clear operative field, and the safety of the medication. |
| NCT07131033 ↗ | Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy | ACTIVE_NOT_RECRUITING | The Second People's Hospital of Huai'an | PHASE1 | 2025-05-06 | Laparoscopic cholecystectomy (LC), while minimally invasive, triggers postoperative fatigue syndrome (POFS) through mechanisms including ischemia-reperfusion injury, neuroendocrine stress (sustained cortisol elevation), and inflammation-driven mitochondrial dysfunction (IDO-mediated kynurenine production). Esketamine, an NMDA receptor antagonist, counteracts POFS by blocking central sensitization, suppressing neuroinflammation (e.g., microglial IL-6 release), and enhancing neuroplasticity via BDNF/TrkB upregulation. Magnesium sulfate complements this by antagonizing NMDA/voltage-gated calcium channels to reduce inflammation and calcium overload, while optimizing cellular energy metabolism as an ATPase cofactor and alleviating muscle spasms. Crucially, their combination holds synergistic potential: esketamine targets central fatigue pathways, while magnesium addresses peripheral metabolic and muscular components. This study aims to determine their individual and interactive effects on POFS, recovery quality, and sleep outcomes in LC patients, establishing an efficient, safe strategy to accelerate postoperative rehabilitation. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
Condition Name
| Condition Name for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE | |
| Intervention | Trials |
| Alleviate Postoperative Fatigue Syndrome | 1 |
| Chronic Rhinosinusitis | 1 |
| Enhanced Recovery After Surgery | 1 |
| Laparoscopic Cholecystectomy | 1 |
| [disabled in preview] | 1 |
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Clinical Trial Locations for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
Clinical Trial Progress for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
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Clinical Trial Sponsors for KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
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