Double Blind Placebo Study of JARDIANCE® (Empagliflozin) in Prehypertensives Type II Diabetics
Aristotle University Of Thessaloniki
1. Primary prevention of new onset of hypertension
1. Reduction of 24h BP in type II diabetics with prehypertension
2. Reduction of non dipping status, day and nighttime BP, morning BP surge in subjects
3. Reduction in the total cardiovascular risk
4. 3 years morbidity and mortality rates
5. Arterial de-stiffening, reduction in central aortic blood pressure in subjects receiving
Effects of Linagliptin in Addition to Empagliflozin on Islet Cell Physiology
Profil Institut für Stoffwechselforschung GmbH
The primary aim of this exploratory mechanistic study is to investigate the effects of
Empagliflozin and Linagliptin on alpha- and beta cell physiology in T2DM patients.
This study aims to evaluate the effect of the DPP-IV inhibitor linagliptin (as compared to
placebo) in addition to the SGLT-2 inhibitor empagliflozin on pancreatic alpha and beta cell
function, as well as several markers of metabolic control.
Effect of Empagliflozin on Macrovascular and Microvascular Circulation and on Endothelium Function
University of Erlangen-Nürnberg Medical School
Empagliflozin may lead to improved vascular and endothelial function in the macro- (pulse
wave reflection) and microcirculation (retinal circulation) and improve cardiovascular risk
factors, imparticular by effectively controlling hyperglycemia, arterial hypertension and
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