A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
The use of hormone contraception poses a significant challenge for the estimated 16 million
HIV-infected women of childbearing age. This is due to known drug interactions with
antiretroviral therapy (medicines used to treat HIV) that may jeopardize contraception
effectiveness. By evaluating the impact of antiretroviral therapy on a levonorgestrel
subdermal implant, the most widely available hormone implant in low and middle-income
countries, this study will translate its findings into an evidence-based approach to
co-manage these important medications. The investigators hypothesize that women receiving
nevirapine or efavirenz-based antiretroviral therapy will have a significant decrease in the
mean levonorgestrel plasma concentration measured six months after the implant's insertion as
compared to those women who are not taking antiretroviral therapy. Although the implant's
efficacy may be retained initially, the investigators propose that a decrease in
levonorgestrel concentrations in women receiving antiretroviral therapy may jeopardize the
implant's effectiveness near the end of its intended duration of use (5 years).
Serving leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.