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Generated: June 20, 2019

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CLINICAL TRIALS PROFILE FOR IVACAFTOR

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Clinical Trials for Ivacaftor

Trial ID Title Status Sponsor Phase Summary
NCT00457821 Safety Study of Ivacaftor in Subjects With Cystic Fibrosis Completed Cystic Fibrosis Foundation Therapeutics Phase 2 The purpose of this study was to evaluate the safety and tolerability of ivacaftor in patients with cystic fibrosis (CF) who were aged 18 years or older and have a G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR protein. Potentiators are pharmacological agents that increase the chloride ion transport properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA) activation.
NCT00457821 Safety Study of Ivacaftor in Subjects With Cystic Fibrosis Completed Vertex Pharmaceuticals Incorporated Phase 2 The purpose of this study was to evaluate the safety and tolerability of ivacaftor in patients with cystic fibrosis (CF) who were aged 18 years or older and have a G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR protein. Potentiators are pharmacological agents that increase the chloride ion transport properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA) activation.
NCT00909532 Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation Completed Cystic Fibrosis Foundation Therapeutics Phase 3 The purpose of this study was to evaluate the efficacy and safety of ivacaftor in subjects with cystic fibrosis aged 12 years and older who have the G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR protein. Potentiators are pharmacological agents that increase the chloride ion transport properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA) activation.
NCT00909532 Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation Completed Vertex Pharmaceuticals Incorporated Phase 3 The purpose of this study was to evaluate the efficacy and safety of ivacaftor in subjects with cystic fibrosis aged 12 years and older who have the G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR protein. Potentiators are pharmacological agents that increase the chloride ion transport properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA) activation.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ivacaftor

Condition Name

Condition Name for Ivacaftor
Intervention Trials
Cystic Fibrosis 85
Diabetes 2
Cystic Fibrosis, Homozygous for the F508del CFTR Mutation 2
Hepatic Impairment 1
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Condition MeSH

Condition MeSH for Ivacaftor
Intervention Trials
Cystic Fibrosis 88
Fibrosis 79
Lung Diseases 3
Lung Diseases, Obstructive 1
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Clinical Trial Locations for Ivacaftor

Trials by Country

Trials by Country for Ivacaftor
Location Trials
United States 868
Canada 68
United Kingdom 61
Australia 46
France 43
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Trials by US State

Trials by US State for Ivacaftor
Location Trials
Massachusetts 41
Missouri 36
Pennsylvania 36
Alabama 35
Illinois 34
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Clinical Trial Progress for Ivacaftor

Clinical Trial Phase

Clinical Trial Phase for Ivacaftor
Clinical Trial Phase Trials
Phase 4 8
Phase 3 40
Phase 2 22
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Clinical Trial Status

Clinical Trial Status for Ivacaftor
Clinical Trial Phase Trials
Completed 34
Recruiting 27
Not yet recruiting 14
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Clinical Trial Sponsors for Ivacaftor

Sponsor Name

Sponsor Name for Ivacaftor
Sponsor Trials
Vertex Pharmaceuticals Incorporated 69
Cystic Fibrosis Foundation Therapeutics 13
University of Alabama at Birmingham 7
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Sponsor Type

Sponsor Type for Ivacaftor
Sponsor Trials
Industry 75
Other 38
NIH 3
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