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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR ISRADIPINE

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Clinical Trials for Isradipine

Trial ID Title Status Sponsor Phase Summary
NCT00753636 Parkinson's Disease Isradipine Safety Study Completed Northwestern Memorial Hospital Phase 2 The objective of this study is to establish the safety and tolerability of isradipine, sustained release preparation in patients with PD. This study is a logical continuation of the project that is being completed now and is conducted in preparation to NIH submission of the pivotal study on the efficacy of this agent for neuroprotection in PD. This study is conducted in parallel with Dr. Surmeier's work on further development of the preclinical data. The focus of his work now is to establishing the correlation between the dose that demonstrated neuroprotective effect in animal model and the dose used for clinical practice. Hypothesis 1: Patients with PD will be able to tolerate isradipine across the FDA recommended dose range. We expect 10% attrition due to hypotensive effect of the agent. Hypothesis 2: Patients with PD and concomitant stable hypertension will be able to tolerate isradipine provided that the dose of the concomitant antihypertensive agent is adjusted based on the blood pressure reading.
NCT00753636 Parkinson's Disease Isradipine Safety Study Completed Northwestern University Phase 2 The objective of this study is to establish the safety and tolerability of isradipine, sustained release preparation in patients with PD. This study is a logical continuation of the project that is being completed now and is conducted in preparation to NIH submission of the pivotal study on the efficacy of this agent for neuroprotection in PD. This study is conducted in parallel with Dr. Surmeier's work on further development of the preclinical data. The focus of his work now is to establishing the correlation between the dose that demonstrated neuroprotective effect in animal model and the dose used for clinical practice. Hypothesis 1: Patients with PD will be able to tolerate isradipine across the FDA recommended dose range. We expect 10% attrition due to hypotensive effect of the agent. Hypothesis 2: Patients with PD and concomitant stable hypertension will be able to tolerate isradipine provided that the dose of the concomitant antihypertensive agent is adjusted based on the blood pressure reading.
NCT00909545 Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease Completed Michael J. Fox Foundation for Parkinson's Research Phase 2 The primary purpose of this study is to establish a dosage of isradipine CR that is tolerable and demonstrates preliminary efficacy for utilization in future pivotal efficacy studies.
NCT00909545 Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease Completed Northwestern University Dixon Fund Phase 2 The primary purpose of this study is to establish a dosage of isradipine CR that is tolerable and demonstrates preliminary efficacy for utilization in future pivotal efficacy studies.
NCT00909545 Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease Completed The Parkinson Study Group Phase 2 The primary purpose of this study is to establish a dosage of isradipine CR that is tolerable and demonstrates preliminary efficacy for utilization in future pivotal efficacy studies.
NCT00909545 Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease Completed Northwestern University Phase 2 The primary purpose of this study is to establish a dosage of isradipine CR that is tolerable and demonstrates preliminary efficacy for utilization in future pivotal efficacy studies.
NCT01658150 Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder Recruiting Brain & Behavior Research Foundation N/A The purpose of this study is to evaluate the use of the drug isradipine for cognitive enhancement in patients diagnosed with schizophrenia and schizoaffective disorder.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Isradipine

Condition Name

Condition Name for Isradipine
Intervention Trials
Parkinson Disease 2
Nicotine Dependence 1
Chronic Spinal Cord Injury 1
Schizophrenia 1
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Condition MeSH

Condition MeSH for Isradipine
Intervention Trials
Parkinson Disease 3
Bipolar Disorder 1
Schizophrenia 1
Psychotic Disorders 1
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Clinical Trial Locations for Isradipine

Trials by Country

Trials by Country for Isradipine
Location Trials
United States 49
Canada 4
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Trials by US State

Trials by US State for Isradipine
Location Trials
New York 3
Illinois 3
Massachusetts 3
Florida 2
Pennsylvania 2
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Clinical Trial Progress for Isradipine

Clinical Trial Phase

Clinical Trial Phase for Isradipine
Clinical Trial Phase Trials
Phase 3 1
Phase 2 3
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Isradipine
Clinical Trial Phase Trials
Completed 3
Unknown status 2
Recruiting 2
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Clinical Trial Sponsors for Isradipine

Sponsor Name

Sponsor Name for Isradipine
Sponsor Trials
Michael J. Fox Foundation for Parkinson's Research 2
Northwestern University 2
The Parkinson Study Group 2
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Sponsor Type

Sponsor Type for Isradipine
Sponsor Trials
Other 15
NIH 2
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