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CLINICAL TRIALS PROFILE FOR ISOSORBIDE MONONITRATE

All Clinical Trials for Isosorbide Mononitrate

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00143195	Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina	Completed	Pfizer	Phase 4	2001-04-01	The objective of study is to compare the anti-ischemic efficacy and safety profiles of once daily amlodipine or isosorbide-5-mononitrate in the treatment of stable asymptomatic and symptomatic myocardial ischemia
NCT00168519	Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes	Completed	Diabetes Australia	N/A	2002-10-01	The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
NCT00168519	Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes	Completed	Hoffmann-La Roche	N/A	2002-10-01	The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
NCT00168519	Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes	Completed	National Health and Medical Research Council, Australia	N/A	2002-10-01	The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
NCT00168519	Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes	Completed	Baker Heart Research Institute	N/A	2002-10-01	The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
NCT00252421	The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis	Completed	Canadian Institutes of Health Research (CIHR)	Phase 3	2005-10-01	Osteoporosis or "thinning of the bones" affects in 1 in 4 Canadian women and 1 in 8 Canadian men. Moreover, while the rates of osteoporosis among Canadians are stabilizing, worldwide the number of people afflicted with osteoporosis continues to rise. The most serious complication of osteoporosis is a broken bone or fracture. Fractures due to osteoporosis can result in long hospital stays, dependence on others, and premature death. While there are several medications that prevent osteoporosis they all have side effects. For example, postmenopausal women who take hormone replacement therapy (HRT) are at increased risk of breast cancer and heart disease. In addition, drugs to prevent osteoporosis are expensive and not available worldwide. Therefore, it is essential that researchers continue to identify and test new medications for the prevention of osteoporosis. The purpose of the research is to determine if nitrates, a group of drugs that are widely available, inexpensive, and commonly used to treat chest pain or angina, can prevent osteoporosis in women. If the researchers find that nitrates prevent osteoporosis, a widely available, inexpensive treatment for osteoporosis prevention that does not have any long term side effects would have been identified. This will improve the health of patients with osteoporosis worldwide.
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