In the Lung Health Study I, to determine the effects of Special Care, compared to Usual
Care, on rate of decline in pulmonary function in a group of cigarette smokers identified as
having mild abnormalities in pulmonary function.
In the Lung Health Study III, to determine the long-term effects of smoking cessation and
continued smoking, on cardiopulmonary morbidity, mortality, and the rate of decline in the
one second forced expiratory volume (FEV1) in men and women with early chronic obstructive
lung disease who have been followed prospectively for 12 to 15 years.
Asthma Clinical Research Network (ACRN) Trial - Long-Acting Beta Agonist Response by Genotype (LARGE)
Asthma Clinical Research Network
The purpose of this trial is to determine whether regularly scheduled use of an inhaled
long-acting beta agonist (salmeterol) in the setting of concomitant use of inhaled
corticosteroids (beclomethasone hydroflouroalkane (HFA) inhaler) will have a detrimental
effect on asthma control in people who bear the B16-Arg/Arg genotype of the beta-2
adrenergic receptor gene, as compared to people with asthma of similar severity who bear the
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