The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation
leads to adverse consequences even if the direct renal effects are positive. Therefore, this
study will look at the effects of direct intrarenal administration of nesiritide on GFR and
RPF.
The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation
leads to adverse consequences even if the direct renal effects are positive. Therefore, this
study will look at the effects of direct intrarenal administration of nesiritide on GFR and
RPF.
Nesiritide and Renal Function After the Total Artificial Heart
Terminated
Virginia Commonwealth University
Phase 4
2013-04-01
The prevalence of renal dysfunction after implantation of the artificial heart is high. The
infusion of exogenous B-type natriuretic peptide (BNP) after implantation of the total
artificial heart (TAH) improves renal function in a sustained manner. The renal protective
and hormone-modulating effects of nesiritide may be enhanced with ventriculectomy compared to
heart failure surgery that leaves the native myocardium intact. The goal of this project is
to determine the renal protective effects of nesiritide after implantation of a mechanical
device.
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