The Safety and Effectiveness of Retrovir Plus HIVID Combined With Either Nevirapine or Invirase in the Treatment of HIV Infection
Completed
Parexel
Phase 2
1969-12-31
To evaluate the tolerance and immunologic and virologic effects of multidrug combinations of
antiretrovirals in patients with HIV infection. Specifically, to evaluate
zidovudine/zalcitabine ( AZT / ddC ) alone or in combination with either nevirapine or
saquinavir ( Ro 31-8959 ).
Administration of three-drug combinations for treatment of HIV infection is preferred over
monotherapy or duotherapy. A system has been designed to rapidly evaluate current multidrug
combinations of antiretrovirals and allow the addition of new agents as they become
available.
Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults
Completed
AIDS Clinical Trials Group
N/A
2003-10-01
HIV replication in resting CD4 cells is so minimal that anti-HIV drugs often fail to destroy
the virus in these cells. Enfuvirtide, also known as T-20, is a type of anti-HIV drug called
a fusion inhibitor. The purpose of this study is to test the ability of a T-20-enhanced
treatment regimen to decrease the number of resting CD4 cells that become infected with HIV.
Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
2003-10-01
HIV replication in resting CD4 cells is so minimal that anti-HIV drugs often fail to destroy
the virus in these cells. Enfuvirtide, also known as T-20, is a type of anti-HIV drug called
a fusion inhibitor. The purpose of this study is to test the ability of a T-20-enhanced
treatment regimen to decrease the number of resting CD4 cells that become infected with HIV.
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