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Last Updated: July 29, 2021

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CLINICAL TRIALS PROFILE FOR INQOVI

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All Clinical Trials for Inqovi

Trial ID Title Status Sponsor Phase Start Date Summary
NCT04655755 ↗ Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Not yet recruiting Astex Pharmaceuticals, Inc. Phase 1/Phase 2 2021-03-31 This phase I/II trial studies the side effects and best dose of venetoclax in combination with cedazuridine and decitabine (ASTX727) in treating patients with high risk myelodysplastic syndrome or chronic myelomonocytic leukemia who have not received prior treatment (treatment-naive). Chemotherapy drugs, such as venetoclax, cedazuridine, and decitabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
NCT04655755 ↗ Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Not yet recruiting Genentech, Inc. Phase 1/Phase 2 2021-03-31 This phase I/II trial studies the side effects and best dose of venetoclax in combination with cedazuridine and decitabine (ASTX727) in treating patients with high risk myelodysplastic syndrome or chronic myelomonocytic leukemia who have not received prior treatment (treatment-naive). Chemotherapy drugs, such as venetoclax, cedazuridine, and decitabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
NCT04655755 ↗ Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Not yet recruiting M.D. Anderson Cancer Center Phase 1/Phase 2 2021-03-31 This phase I/II trial studies the side effects and best dose of venetoclax in combination with cedazuridine and decitabine (ASTX727) in treating patients with high risk myelodysplastic syndrome or chronic myelomonocytic leukemia who have not received prior treatment (treatment-naive). Chemotherapy drugs, such as venetoclax, cedazuridine, and decitabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
NCT04657081 ↗ Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML) Not yet recruiting Astex Pharmaceuticals, Inc. Phase 1 2020-12-31 This is a single-arm, open-label, multicenter, non-randomized interventional study to evaluate the pharmacokinetic (PK) interaction, safety, and preliminary efficacy of ASTX727 when given in combination with venetoclax for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults who are age 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy. The primary purpose of the study is to rule out drug-drug interactions between ASTX727 and venetoclax combination therapy by evaluating area under the curve (AUC) and maximum plasma concentration (Cmax) exposure.
NCT04746235 ↗ Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia Not yet recruiting M.D. Anderson Cancer Center Phase 2 2021-05-31 This phase II trial studies the possible benefits of venetoclax and ASTX727 in treating patients with acute myeloid leukemia that has come back (relapsed) or does not respond to treatment (refractory), or elderly patients with newly diagnosed acute myeloid leukemia who are not candidates for intensive chemotherapy. Venetoclax may help block the formation of growths that may become cancer. ASTX727 is the combination of a fixed dose of 2 drugs, cedazuridine and decitabine. Cedazuridine may slow down how fast decitabine is broken down by the body, and decitabine may block abnormal cells or cancer cells from growing. Giving venetoclax and ASTX727 may help to control the disease.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Inqovi

Condition Name

Condition Name for Inqovi
Intervention Trials
Acute Myeloid Leukemia 4
Refractory Acute Myeloid Leukemia 2
Recurrent Acute Myeloid Leukemia 2
Chronic Myelomonocytic Leukemia 1
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Condition MeSH

Condition MeSH for Inqovi
Intervention Trials
Leukemia 5
Leukemia, Myeloid, Acute 4
Leukemia, Myeloid 4
Syndrome 2
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Clinical Trial Locations for Inqovi

Trials by Country

Trials by Country for Inqovi
Location Trials
United States 3
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Trials by US State

Trials by US State for Inqovi
Location Trials
Texas 3
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Clinical Trial Progress for Inqovi

Clinical Trial Phase

Clinical Trial Phase for Inqovi
Clinical Trial Phase Trials
Phase 2 2
Phase 1/Phase 2 3
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Inqovi
Clinical Trial Phase Trials
Not yet recruiting 6
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Clinical Trial Sponsors for Inqovi

Sponsor Name

Sponsor Name for Inqovi
Sponsor Trials
M.D. Anderson Cancer Center 3
Astex Pharmaceuticals, Inc. 2
Novartis Pharmaceuticals 1
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Sponsor Type

Sponsor Type for Inqovi
Sponsor Trials
Industry 4
Other 3
NIH 1
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