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Generated: September 18, 2018

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CLINICAL TRIALS PROFILE FOR INDOMETHACIN

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Clinical Trials for Indomethacin

Trial ID Title Status Sponsor Phase Summary
NCT00000494 Management of Patent Ductus in Premature Infants Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 To evaluate the effects (up to one year of age) of indomethacin on the clinical course of patent ductus arteriosus (PDA) in premature infants (24 hours old or less) and to assess the relative merits of indomethacin and surgery in infants with persistent respiratory distress who were not treated early with indomethacin. Two concurrent trials were performed.
NCT00002535 Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma Completed St. Luke's Medical Center Phase 2 RATIONALE: Biological therapies use different ways to stimulate the immune system and stop tumor cells from growing. Combining biological therapies with indomethacin and cyclophosphamide may kill more tumor cells. PURPOSE: Phase II trial to compare the effectiveness of indomethacin and biological therapy with or without cyclophosphamide in treating patients who have advanced melanoma that has not responded to previous therapy.
NCT00002796 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer Terminated National Cancer Institute (NCI) Phase 1/Phase 2 Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor cells. This phase I/II trial is studying the side effects and best dose of giving fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how well it works in treating patients with stage IV colorectal cancer
NCT00004778 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery Completed Children's Hospital of Philadelphia Phase 3 OBJECTIVES: I. Evaluate the effect of thyrotropin-releasing hormone (TRH) on the severity of initial lung disease and occurrence of chronic lung disease when given antenatally to women with threatened premature delivery. II. Evaluate possible mechanisms for the effects of TRH on the severity and incidence of chronic lung disease. III. Investigate whether a deficiency in endogenous cortisol and/or thyroid hormones after birth influences the severity of lung disease and the development of chronic lung disease.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Indomethacin

Condition Name

Condition Name for Indomethacin
Intervention Trials
Patent Ductus Arteriosus 10
Pancreatitis 5
Ductus Arteriosus, Patent 5
Post-ERCP Acute Pancreatitis 4
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Condition MeSH

Condition MeSH for Indomethacin
Intervention Trials
Ductus Arteriosus, Patent 19
Pancreatitis 17
Premature Birth 12
Obstetric Labor, Premature 8
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Clinical Trial Locations for Indomethacin

Trials by Country

Trials by Country for Indomethacin
Location Trials
United States 228
Canada 23
China 14
Mexico 7
Australia 7
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Trials by US State

Trials by US State for Indomethacin
Location Trials
California 16
Texas 14
Michigan 12
Pennsylvania 10
Ohio 10
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Clinical Trial Progress for Indomethacin

Clinical Trial Phase

Clinical Trial Phase for Indomethacin
Clinical Trial Phase Trials
Phase 4 32
Phase 3 24
Phase 2/Phase 3 6
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Clinical Trial Status

Clinical Trial Status for Indomethacin
Clinical Trial Phase Trials
Completed 57
Recruiting 23
Not yet recruiting 12
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Clinical Trial Sponsors for Indomethacin

Sponsor Name

Sponsor Name for Indomethacin
Sponsor Trials
National Cancer Institute (NCI) 4
China Medical University Hospital 4
Chelsea Therapeutics 4
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Sponsor Type

Sponsor Type for Indomethacin
Sponsor Trials
Other 131
Industry 33
NIH 13
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Serving hundreds of leading biopharmaceutical companies globally:

AstraZeneca
US Department of Justice
Cantor Fitzgerald
QuintilesIMS
Covington
Daiichi Sankyo
Express Scripts
Cerilliant
Fuji

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