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Generated: February 19, 2019

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CLINICAL TRIALS PROFILE FOR INDOCYANINE GREEN

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Clinical Trials for Indocyanine Green

Trial ID Title Status Sponsor Phase Summary
NCT00002901 Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function Completed National Cancer Institute (NCI) Phase 1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of docetaxel in treating patients with advanced solid tumors that have not responded to standard therapy or for which there is no effective therapy.
NCT00002901 Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function Completed City of Hope Medical Center Phase 1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of docetaxel in treating patients with advanced solid tumors that have not responded to standard therapy or for which there is no effective therapy.
NCT00043680 Celecoxib to Treat Macular Degeneration in Patients Receiving Photodynamic Therapy Completed National Eye Institute (NEI) Phase 2 This study will determine whether the drug celecoxib (Celebrex® (Registered Trademark)) can help stabilize or improve vision in patients with age-related macular degeneration (AMD) who are receiving photodynamic therapy, or PDT (also called cold laser treatment). The macula is the part of the retina in the back of the eye that determines central or best vision. AMD can severely impair central vision, affecting a person's ability to read, drive, and carry out daily activities. This vision loss is caused by the formation of abnormal new blood vessels in the choroid-a thin, pigmented vascular layer of the eye behind the retina-that leak blood under the macula. PTD stops the growth of these blood vessels and slows the rate of vision loss. However, the treatment usually does not cause vision to improve, and it has only a temporary effect, requiring several treatments over 2 years. Furthermore, PDT does not work in all patients and may actually cause some swelling and re-growth of blood vessels. Celecoxib is an anti-inflammatory drug that, in animal studies, has prevented the growth of abnormal blood vessels associated with tumors and with injury to the cornea. Thus, the drug might reduce swelling and prevent vessel re-growth in AMD, enhancing the effectiveness of PDT. Patients 55 years of age and older with AMD and visual acuity of 20/20 to 20/200 may be eligible for this study. Participants will be randomly assigned to take either celecoxib or a placebo (a look-alike pill with no active drug) twice a day and undergo the various tests and procedures detailed below. Not every examination will be done at every visit, but all may be required at one visit. - Medical history and physical examination - Blood drawing: A blood sample is drawn from an arm vein to evaluate liver and kidney function - Eye examination: Visual acuity and eye pressure are measured, and the lens, retina, pupils and eye movements are examined - Photography: Photographs of the eye are taken using a special camera with a bright flash - Fluorescein angiography: Pictures of the retina are taken to look for abnormal blood vessels. A yellow dye is injected into an arm vein and travels to the blood vessels in the eyes. The retina is photographed using a camera that flashes a blue light into the eye. The pictures show if any dye has leaked from the vessels into the retina, indicating possible blood vessel abnormality. - Indocyanine green angiography: This procedure, similar to fluorescein angiography, uses a green dye to photograph the retina and identify portions of abnormal vessels in the deepest part of the retina. - Optical coherence tomography: This new technique uses light to produce a 2-dimensional cross-sectional picture of the retina. The patient looks into a machine called an optical coherence tomograph at a pattern of flashing and rotating red and green lights, first with one eye and then the other. One week after starting the study medications, laser treatment will begin. For this procedure, a needle is placed in an arm vein and a chemical called verteporfin (Visudyne® (Registered Trademark)) is infused into the vein over 10 minutes. After 15 minutes, the eye is anesthetized with numbing drops. A special contact lens is then placed on the eye and the laser beam is directed to the eye for 83 seconds. Patients will be followed in the clinic every 6 weeks for 36 weeks for various examinations and possible re-treatment, if needed. Some patients will be asked to return 1 to 2 weeks after the first PDT for an eye examination and fluorescein angiography.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Indocyanine Green

Condition Name

Condition Name for Indocyanine Green
Intervention Trials
Breast Cancer 13
Polypoidal Choroidal Vasculopathy 8
Macular Degeneration 5
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Condition MeSH

Condition MeSH for Indocyanine Green
Intervention Trials
Breast Neoplasms 15
Macular Degeneration 13
Vascular Diseases 9
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Clinical Trial Locations for Indocyanine Green

Trials by Country

Trials by Country for Indocyanine Green
Location Trials
United States 74
Korea, Republic of 13
France 9
Belgium 8
China 8
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Trials by US State

Trials by US State for Indocyanine Green
Location Trials
Maryland 11
California 11
Ohio 8
New York 7
Massachusetts 7
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Clinical Trial Progress for Indocyanine Green

Clinical Trial Phase

Clinical Trial Phase for Indocyanine Green
Clinical Trial Phase Trials
Phase 4 12
Phase 3 10
Phase 2/Phase 3 6
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Clinical Trial Status

Clinical Trial Status for Indocyanine Green
Clinical Trial Phase Trials
Completed 56
Recruiting 45
Not yet recruiting 15
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Clinical Trial Sponsors for Indocyanine Green

Sponsor Name

Sponsor Name for Indocyanine Green
Sponsor Trials
National Cancer Institute (NCI) 14
National Eye Institute (NEI) 11
Jules Bordet Institute 6
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Sponsor Type

Sponsor Type for Indocyanine Green
Sponsor Trials
Other 160
NIH 29
Industry 28
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Serving hundreds of leading biopharmaceutical companies globally:

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AstraZeneca
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McKinsey

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