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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR IFOSFAMIDE

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Clinical Trials for Ifosfamide

Trial ID Title Status Sponsor Phase Summary
NCT00001209 A Pilot Study for the Treatment of Patients With Metastatic and High Risk Sarcomas and Primitive Neuroectodermal Tumors Completed National Cancer Institute (NCI) Phase 1 This protocol is designed to test the feasibility of the administration of vincristine, adriamycin and cytoxan, alternating with the newly developed regimen ifosfamide VP-16 as well as the efficacy of this therapy in addition to radiotherapy in producing complete responses and disease-free survival in patients with Ewing's sarcoma, primitive sarcoma of bone, peripheral neuroepithelioma, and soft tissue sarcoma. This will not be a randomized study but will be comparable to the large data base of similar patients treated on successive Pediatric Branch studies.
NCT00001270 Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma Completed National Cancer Institute (NCI) Phase 1 This is a phase I/II study of interleukin-1, G-CSF and high dose ICE chemotherapy with autologous bone marrow transplant in patients with relapsed breast, testicular and lymphoid cancers. The initial goal of this study was to define the toxicity of interleukin-1 administered for 7 days prior to ICE chemotherapy. A total of 22 patients have been treated with IL-1 and ICE and results showed a more rapid engraftment (4.5 days) with IL-1. A second cohort of 18 patients also received G-CSF and engraftment was further shortened in some subgroups. Overall, the median time to engraftment was 16 days with both IL-1 and G-CSF. Accrual will continue to further define the toxicity and efficacy of this regimen.
NCT00001300 A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma Completed National Cancer Institute (NCI) Phase 3 Randomized study. All patients must be randomized to treatment on Arms I and II within 3 months of definitive surgery on Regimen A. Regimen A: Surgery followed, as indicated, by Radiotherapy. Amputation; or limb-sparing resection followed by involved-field irradiation using megavoltage equipment with or without electron boost. Arm I: 2-Drug Combination Chemotherapy with Hematologic Toxicity Attenuation and Urothelial Protection. Doxorubicin, DOX, NSC-123127; Ifosfamide, IFF, NSC-109724; with Granulocyte Colony Stimulating Factor (Amgen), G-CSF, NSC-614629; and Mesna, NSC-113891. Arm II: Observation. No adjuvant chemotherapy.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ifosfamide

Condition Name

Condition Name for Ifosfamide
Intervention Trials
Sarcoma 60
Lymphoma 55
Leukemia 20
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Condition MeSH

Condition MeSH for Ifosfamide
Intervention Trials
Lymphoma 123
Sarcoma 103
Lymphoma, Non-Hodgkin 42
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Clinical Trial Locations for Ifosfamide

Trials by Country

Trials by Country for Ifosfamide
Location Trials
Canada 194
Australia 74
Italy 67
United Kingdom 60
France 53
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Trials by US State

Trials by US State for Ifosfamide
Location Trials
New York 83
California 74
Texas 70
Pennsylvania 55
Illinois 54
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Clinical Trial Progress for Ifosfamide

Clinical Trial Phase

Clinical Trial Phase for Ifosfamide
Clinical Trial Phase Trials
Phase 4 8
Phase 3 75
Phase 2/Phase 3 6
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Clinical Trial Status

Clinical Trial Status for Ifosfamide
Clinical Trial Phase Trials
Completed 156
Recruiting 75
Unknown status 45
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Clinical Trial Sponsors for Ifosfamide

Sponsor Name

Sponsor Name for Ifosfamide
Sponsor Trials
National Cancer Institute (NCI) 124
Children's Oncology Group 24
Memorial Sloan Kettering Cancer Center 23
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Sponsor Type

Sponsor Type for Ifosfamide
Sponsor Trials
Other 442
NIH 127
Industry 82
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