CLINICAL TRIALS PROFILE FOR ISUPREL

All Clinical Trials for ISUPREL

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT02615119 ↗	Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa	Recruiting	National Institute of Mental Health (NIMH)	N/A	2015-10-01	This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.
NCT02615119 ↗	Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa	Recruiting	Laureate Institute for Brain Research, Inc.	N/A	2015-10-01	This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.
NCT02673996 ↗	POTS Adrenergic Ab (CIHR Aims #1&2)	Recruiting	University of Calgary		2016-01-01	Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.
NCT02725060 ↗	Autoimmune Basis for Postural Tachycardia Syndrome	Enrolling by invitation	University of Oklahoma	N/A	2016-02-01	The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these autoantibodies make a difference in their POTS symptoms. The investigators also want to see if the levels of these autoantibodies stay the same over time.
NCT02725060 ↗	Autoimmune Basis for Postural Tachycardia Syndrome	Enrolling by invitation	Vanderbilt University	N/A	2016-02-01	The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these autoantibodies make a difference in their POTS symptoms. The investigators also want to see if the levels of these autoantibodies stay the same over time.

Clinical Trial Conditions for ISUPREL

Condition Name

Condition Name for ISUPREL
Intervention	Trials
Anorexia Nervosa	2
Postural Tachycardia Syndrome	2
Orthostatic Intolerance	1
Panic Disorder	1

Condition MeSH

Condition MeSH for ISUPREL
Intervention	Trials
Postural Orthostatic Tachycardia Syndrome	2
Anorexia Nervosa	2
Anorexia	2
Tachycardia	2

Clinical Trial Locations for ISUPREL

Trials by Country

Trials by Country for ISUPREL
Location	Trials
United States	5
Canada	1

Trials by US State

Trials by US State for ISUPREL
Location	Trials
Oklahoma	3
Michigan	1
Tennessee	1

Clinical Trial Progress for ISUPREL

Clinical Trial Phase

Clinical Trial Phase for ISUPREL
Clinical Trial Phase	Trials
Phase 2	1
N/A	3

Clinical Trial Status

Clinical Trial Status for ISUPREL
Clinical Trial Phase	Trials
Recruiting	2
Active, not recruiting	1
Completed	1

Clinical Trial Sponsors for ISUPREL

Sponsor Name

Sponsor Name for ISUPREL
Sponsor	Trials
Laureate Institute for Brain Research, Inc.	2
Brain & Behavior Research Foundation	1
University of Michigan	1

Sponsor Type

Sponsor Type for ISUPREL
Sponsor	Trials
Other	8
NIH	1

ISUPREL (isoproterenol) Clinical Trials Update, Market Analysis, and Projection

Last updated: May 2, 2026

What is ISUPREL and what is the current clinical-trial signal?

ISUPREL is the brand name for isoproterenol hydrochloride, an older sympathomimetic beta-adrenergic agonist. It is historically used for bradyarrhythmias and related acute indications requiring beta stimulation.

A full, trial-by-trial clinical update cannot be produced from the information provided. No dataset or filing set was included that identifies:

• active or completed interventional trials for ISUPREL specifically (not isoproterenol generics),
• the clinical trial record IDs (e.g., NCT numbers),
• endpoints, sample sizes, or results,
• regulatory submissions tied to trial outcomes.

With no trial registry data or publication list supplied, the only defensible statement is that a current clinical-trials update for ISUPREL cannot be constructed without external trial-identifying inputs.

What is the commercial landscape for isoproterenol brands like ISUPREL?

ISUPREL’s commercial footprint is shaped by four forces: product age, generic substitution, shifting standard-of-care, and regulatory/availability changes over decades.

Market structure

• Active ingredient: isoproterenol (generic).
• Branding: ISUPREL is a historical brand; in many markets, generic isoproterenol products dominate.
• Therapeutic positioning: acute care beta-agonist use for bradycardia and related settings has faced competition from other agents and pacing strategies, which changes tender dynamics and hospital formularies.

Demand drivers and constraints

Demand drivers

• Acute bradycardia and peri-procedural needs where beta-adrenergic stimulation is used.
• Stocking policies that preserve access to older agents as backup options.

Constraints

• Generic pricing pressure limits brand-level revenue growth.
• Formulary preference shifts toward alternatives with broader adoption or easier administration protocols.
• Manufacturing and supply continuity become a major revenue determinant for older injectable products.

What can be projected without trial or pricing inputs?

No credible market projection can be generated without at least one of the following:

• current unit sales, net revenue, or volumes by country,
• wholesaler or channel data,
• pricing history (ex-manufacturer or tender),
• identified competitor set and their market shares.

No such inputs are available in the provided prompt; therefore, a quantitative market projection for ISUPREL cannot be produced.

What are the most actionable business implications given ISUPREL’s profile?

Even without new trial or financial datasets, the business implications are constrained to product lifecycle realities:

1. Brand differentiation is weak if the molecule is widely generic. ISUPREL-specific share depends more on supply reliability, tender inclusion, and packaging/labeling than on clinical differentiation.

2. Acute-care injectable demand behaves like “availability equity.” Revenue volatility often correlates with supply continuity, not with long-run incidence growth.

3. Modern clinical practice reduces upside for old beta agonists. The main path to incremental demand usually comes from hospital protocol changes or emergency-use stocking mandates.

4. Regulatory continuity matters. For older injectables, the most material business events are manufacturing changes, label updates, and supply interruptions that trigger substitution or procurement shifts.

What is the patent and regulatory status relevance for ISUPREL?

A patent status analysis for ISUPREL requires specific patent family identifiers, expiry dates, and regulatory exclusivity periods. No patent or regulatory dossier identifiers were provided, so a defensible status timeline cannot be generated.

Key Takeaways

• Clinical trials update: A complete, factual trial-by-trial update for ISUPREL cannot be produced from the provided input.
• Market analysis: ISUPREL faces generic substitution and acute-care formulary pressure, with demand tied more to availability and tender inclusion than to expansion prospects.
• Market projection: A quantitative projection cannot be produced without sales, pricing, or channel-volume inputs.
• Next decisions: Any investment or R&D decision for ISUPREL depends on confirmed trial signals, current supply/pricing conditions, and patent/regulatory timelines tied to specific filings.

FAQs

1. Is ISUPREL still being studied in clinical trials?
   A current, evidence-backed clinical-trials update cannot be provided without trial registry identifiers or a supplied list of study records.

2. Is ISUPREL protected by active patents?
   Patent status cannot be stated from the provided prompt because no patent family data was included.

3. Why does ISUPREL’s market outlook depend on supply more than demand growth?
   Injectable older molecules often trade primarily on hospital availability, tender inclusion, and continuity of manufacturing.

4. What typically competes with isoproterenol in bradycardia indications?
   Competitive dynamics exist in acute-care protocols, but a competitor set and market-share mapping cannot be created without current formulary and channel data.

5. Can a market projection be made from qualitative drivers alone?
   No. Quantitative projections require baseline revenue/volume, pricing, and competitive share data.

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References

[1] U.S. Food and Drug Administration. (n.d.). Drugs@FDA. https://www.accessdata.fda.gov/scripts/cder/daf/
[2] National Library of Medicine. (n.d.). ClinicalTrials.gov. https://clinicaltrials.gov/