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Generated: December 11, 2017

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CLINICAL TRIALS PROFILE FOR
INSULIN

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Clinical Trial Listing

Trial ID Title Status Sponsor Phase Summary
NCT00000110 Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLACompletedNational Center for Research Resources (NCRR)N/A The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS) to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged bout of endurance running and, 2) determine the pattern (time course) of IML replenishment following an extremely low-fat diet (10% of energy from fat) and a moderate-fat diet (35% of energy from fat). Specifically, the study will evaluate the change in IML following a 2-hour training run and the recovery of IML in response to the post-exercise low-fat or moderate-fat diet in 10 endurance trained athletes who will consume both diets in a randomly assigned cross-over fashion. We hypothesize that IML will be depleted with prolonged endurance exercise, and that replenishment of IML will be impaired by an extremely low-fat diet compared to a moderate-fat diet. Results of this pilot study will be used to apply for extramural grant support from NIH or the US Armed Forces to investigate the effect of dietary fat on the health and performance of individuals performing heavy physical training. It is anticipated that this methodology could also be employed in obesity research to delineate, longitudinally, the reported cross-sectional relationships among IML stores, insulin resistance and obesity.
NCT00000159 Sorbinil Retinopathy Trial (SRT)CompletedNational Eye Institute (NEI)Phase 3 To evaluate the safety and efficacy of the investigational drug sorbinil, an aldose reductase inhibitor, in preventing the development of diabetic retinopathy and neuropathy in persons with insulin-dependent diabetes.
NCT00000380 Growth Hormone Releasing Hormone (GHRH) Treatment for Age-Related Sleep DisturbancesCompletedNational Institute of Mental Health (NIMH)N/A The purpose of this study is to examine the effects of giving growth hormone releasing hormone (GHRH) to treat sleep disorders in older men and in older women who are on estrogen replacement therapy (ERT). Many older men and women complain of sleep disturbances. GHRH has been used successfully to treat sleep disorders in young men and may help older men and women. 40 healthy older men and 40 healthy older women on ERT will receive either GHRH or an inactive placebo. An individual may be eligible for this study if he/she is a healthy older man or woman with sleep disturbances, and is on estrogen replacement therapy (women).
NCT00000380 Growth Hormone Releasing Hormone (GHRH) Treatment for Age-Related Sleep DisturbancesCompletedUniversity of WashingtonN/A The purpose of this study is to examine the effects of giving growth hormone releasing hormone (GHRH) to treat sleep disorders in older men and in older women who are on estrogen replacement therapy (ERT). Many older men and women complain of sleep disturbances. GHRH has been used successfully to treat sleep disorders in young men and may help older men and women. 40 healthy older men and 40 healthy older women on ERT will receive either GHRH or an inactive placebo. An individual may be eligible for this study if he/she is a healthy older man or woman with sleep disturbances, and is on estrogen replacement therapy (women).
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI)CompletedEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Phase 3 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI)CompletedNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Phase 3 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI)CompletedNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Phase 3 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI)CompletedNational Institute on Aging (NIA)Phase 3 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI)CompletedNational Heart, Lung, and Blood Institute (NHLBI)Phase 3 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000549 Estrogen Replacement and Atherosclerosis (ERA) in Older WomenCompletedNational Heart, Lung, and Blood Institute (NHLBI)Phase 3 To determine if estrogen replacement therapy, with or without low dose progesterone, slows progression or induces regression of coronary atherosclerosis in postmenopausal women.
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Conditions

Condition Name

Condition Name for INSULIN
Intervention Trials
Diabetes Mellitus, Type 2 569
Diabetes 560
Type 2 Diabetes Mellitus 316
Diabetes Mellitus, Type 1 288
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Condition MeSH

Condition MeSH for INSULIN
Intervention Trials
Diabetes Mellitus 1897
Diabetes Mellitus, Type 2 1246
Diabetes Mellitus, Type 1 622
Insulin Resistance 411
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Trial Locations

Trials by Country

Trials by Country for INSULIN
Location Trials
Argentina 96
Hungary 94
Finland 91
Czech Republic 91
Taiwan 83
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Trials by US State

Trials by US State for INSULIN
Location Trials
California 544
Texas 504
New York 384
Florida 358
Pennsylvania 307
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Clinical Trial Progress

Clinical Trial Phase

Clinical Trial Phase for INSULIN
Clinical Trial Phase Trials
Phase 4 1030
Phase 3 724
Phase 2/Phase 3 111
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Clinical Trial Status

Clinical Trial Status for INSULIN
Clinical Trial Phase Trials
Completed 2415
Recruiting 552
Unknown status 339
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Clinical Trial Sponsors

Sponsor Name

Sponsor Name for INSULIN
Sponsor Trials
Novo Nordisk A/S 498
Sanofi 234
Eli Lilly and Company 174
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Sponsor Type

Sponsor Type for INSULIN
Sponsor Trials
Other 3610
Industry 2051
NIH 515
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Serving leading biopharmaceutical companies globally:

Argus Health
Moodys
AstraZeneca
Boehringer Ingelheim
Mallinckrodt
US Army
Chinese Patent Office
Medtronic
Chubb
Covington

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