CLINICAL TRIALS PROFILE FOR IMIPENEM AND CILASTATIN
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All Clinical Trials for IMIPENEM AND CILASTATIN
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00080496 ↗ | Study Evaluating Tigecycline Versus Imipenem/Cilastatin in Hospital-Acquired Pneumonia | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 | 2003-07-01 | To compare the efficacy and safety of the tigecycline regimen with that of the imipenem/cilastatin regimen in subjects with nosocomial pneumonia. |
| NCT00081744 ↗ | Study Comparing Tigecycline to Imipenem/Cilastatin in Complicated Intra-Abdominal Infections in Hospitalized Subjects | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 | 2002-11-01 | Purpose: To provide a mechanism for the emergency use of tigecycline in the appropriate clinical situations. |
| NCT00136201 ↗ | Study Comparing Tigecycline and Imipenem/Cilastatin in Chinese Subjects With Complicated Intra-Abdominal Infections | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 | 2005-11-01 |
The primary objective of this study is to compare the safety and efficacy of an experimental
antibiotic to a marketed antibiotic in the treatment of Chinese subjects with complicated
intra-abdominal infections. |
| NCT00236834 ↗ | A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired During Hospitalization | Completed | PriCara, Unit of Ortho-McNeil, Inc. | Phase 3 | 1997-12-01 | The purpose of this study is to compare the safety and effectiveness of levofloxacin with imipenem/cilastatin in the treatment of hospital-acquired pneumonia |
| NCT00236834 ↗ | A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired During Hospitalization | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 | 1997-12-01 | The purpose of this study is to compare the safety and effectiveness of levofloxacin with imipenem/cilastatin in the treatment of hospital-acquired pneumonia |
| NCT00515034 ↗ | A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 2 | 2007-10-01 | The purpose of this study is to assess the safety and tolerability of doripenem compared to imipenem in Ventilator-assisted pneumonia and complicated Intra-abdominal Infection. The study population will include hospitalized patients (or patients resident in a chronic health care facility) who have a diagnosis of either Ventilator associated pneumonia or complicated Intra-abdominal Infection. |
| NCT00579956 ↗ | A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis | Unknown status | Mahidol University | N/A | 2007-12-01 | Melioidosis, an infection caused by the bacterium Burkholderia pseudomallei, is a major cause of community-acquired septicaemia in northeast Thailand. Common manifestations include cavitating pneumonia, hepatic and splenic abscesses, and soft tissue and joint infections. Despite improvements in diagnostic procedures and treatment, the mortality of severe melioidosis remains unacceptably high - approximately 35% with currently used antibiotics (ceftazidime or co-amoxiclav). There is clear evidence that antibiotics can affect mortality; the use of ceftazidime rather than previous regimens (doxycycline + chloramphenicol + co-trimoxazole) led to a 50% reduction in mortality from 80% to 35%. However, the mortality in the first 48 hours has not been altered by any treatment regimen. A key question is whether alternative antibiotics could improve early outcome. The hypothesis tested is that meropenem is superior to ceftazidime in terms of mortality for the treatment of melioidosis. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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