Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
Completed
Shire
Phase 2/Phase 3
2007-08-21
This is a randomised, controlled, open, two-armed, two-period cross-over, multi-centre phase
II/III study to assess the safety, tolerability and pharmacokinetics of once-daily oral
modified-release hydrocortisone in comparison to conventional thrice-daily oral
hydrocortisone tablets in patients with adrenal insufficiency
Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu
Terminated
Assistance Publique - Hôpitaux de Paris
Phase 3
2010-03-01
The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is
rapidly progressing worldwide and a substantial number of patients get severe H1N1 related
pneumonia that requires mechanical ventilation and admission to the intensive care unit. The
acute respiratory distress syndrome is associated with a substantial mortality and morbidity
partly as a consequence of uncontrolled lung and systemic inflammation. many physicians are
trying to counteract this pro-inflammatory storm by the use of corticosteroids albeit these
drugs may cause super infection or metabolic disorders. Thus, there is a need for a
randomized double blind, placebo controlled trial to define the benefit to risk ratio of
corticosteroids in this patient.
Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu
Terminated
University of Versailles
Phase 3
2010-03-01
The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is
rapidly progressing worldwide and a substantial number of patients get severe H1N1 related
pneumonia that requires mechanical ventilation and admission to the intensive care unit. The
acute respiratory distress syndrome is associated with a substantial mortality and morbidity
partly as a consequence of uncontrolled lung and systemic inflammation. many physicians are
trying to counteract this pro-inflammatory storm by the use of corticosteroids albeit these
drugs may cause super infection or metabolic disorders. Thus, there is a need for a
randomized double blind, placebo controlled trial to define the benefit to risk ratio of
corticosteroids in this patient.
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