Comparison of a Twice Daily Versus a Three Times Daily Insulin Regimen in Children With Type 1 Diabetes
University of Calgary
The purpose of this study is to determine whether there is a difference in blood sugar
control (as measured by hemoglobin A1c (HA1c)), in children given twice daily insulin
injections incorporating a new long acting insulin analogue (detemir) compared to children
using their current three times a day insulin injections (with intermediate and rapid acting
Effect of Single Dose Intranasal Insulin On Cognitive Function
University of Massachusetts, Worcester
The purpose of the study is to find out how a small dose of insulin might affect memory, the
ability to concentrate, and improve your daily functioning in patients with schizophrenia
and schizoaffective disorders. Insulin is not being used to treat diabetes in this study.
The investigators propose a single dose, double-blinded, placebo-controlled trial of
intranasal insulin in 40 subjects with schizophrenia or schizoaffective disorder to examine
insulin's effect on cognition. The specific aims include:
1. Examine the effects of single doses of 40 IU intranasal insulin compared to placebo on
cognitive functioning, including attention and memory.
2. Examine whether single dose of intranasal insulin administration will raise serum
insulin level and decrease plasma glucose level
Insulin will be delivered through an air spray pump into your nose. The investigators will
be comparing one dose of insulin (40 International Units) with placebo, an inactive liquid.
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